Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities
文献类型：期刊论文
| 作者 | Yue, Jingyi; Zhang, Nan; Xu, Tao; Wang, Jutao; Cai, Baixiang; Yu, Yang |
| 刊名 | MOLECULES
 |
| 出版日期 | 2022 |
| 卷号 | 27期号:22页码:7676 |
| 关键词 | phenylpropanoid Asparagus cochinchinensis anti-inflammatory activity PHENANTHRENE EXTRACT |
| DOI | 10.3390/molecules27227676 |
| 英文摘要 | Three undescribed phenylpropanoid derivatives, including two new bibenzyl constituents (1-2), one new stilbene constituent (3), together with five known compounds stilbostemin F (4), dihydropinosylvin (5), 2-(4-hydroxyphenyl)ethyl benzoate (6), 1-(4-hydroxybenzoyl)ethanone (7), and 4-hydroxy-3-prenylbenzoic acid (8), were isolated from the tuber of Asparagus cochinchinensis. The structures of 1-8 were elucidated according to UV, IR, HRMS, 1D and 2D-NMR methods together with the published literature. All of the isolated compounds were assessed for anti-inflammatory activity by acting on lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells in vitro. The results showed that compounds 2 and 5 were found to inhibit the production of nitric oxide (NO) with the IC50 value of 21.7 and 35.8 mu M, respectively. In addition, further studies found that compound 2 demonstrated concentration-dependent suppression of the protein expression of iNOS and exerted anti-inflammatory activity via the NF-kappa B signalling pathway. The present data suggest that phenylpropanoid derivatives from the tuber of A. cochinchinensis might be used as a potential source of natural anti-inflammatory agents. |
| WOS记录号 | WOS:000888118700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74765]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yue, Jingyi,Zhang, Nan,Xu, Tao,et al. Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities[J]. MOLECULES,2022,27(22):7676. |
| APA | Yue, Jingyi,Zhang, Nan,Xu, Tao,Wang, Jutao,Cai, Baixiang,&Yu, Yang.(2022).Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities.MOLECULES,27(22),7676. |
| MLA | Yue, Jingyi,et al."Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities".MOLECULES 27.22(2022):7676. |
入库方式： OAI收割
来源：昆明植物研究所
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