Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin
文献类型：期刊论文
| 作者 | Zhu, Xiang; Na, Xin; Zeng, Yueqin; Xu, Yangantai; Chai, Dongya; Yang, Huanzhi; Miao, Jingqian; Zhang, Yuan; Yang, Fenghua; Wang, Yuehu
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| 刊名 | MOLECULAR & CELLULAR TOXICOLOGY
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| 出版日期 | 2022 |
| 卷号 | 18期号:3页码:359-369 |
| 关键词 | Polyphyllin I Chemosensitization Doxorubicin Immunotoxicity Hemolysis BREAST-CANCER CELLS SAPONIN INHIBITION RESISTANCE CISPLATIN |
| DOI | 10.1007/s13273-021-00206-w |
| 英文摘要 | Background Polyphyllin I (PPI), a steroidal saponin, exhibits antitumor activity and chemosensitization effect for a broad spectrum of cancer cells, however, its toxicity and chemosensitization effect in vivo is still unknown. Objective We investigated PPI's cytotoxic activity, toxicity and chemosensitization effect and in vitro and in vivo. Results The IC50 values of PPI on MCF-7, H22, and S180 tumor cells were 4.37 mu mol/L, 1.71 mu mol/L, and 0.92 mu mol/L, respectively. The LD50 of PPI was found to be 47.9 mg/kg using ip. injection. PPI at concentrations of 0.3 mg/kg, 0.6 mg/kg, 1.2 mg/kg, and 2.4 mg/kg (1/80 LD50-1/20 LD50) were synergized with DOX of 0.5 mg/kg to inhibit the H22 and S180 tumor growth in vivo by inducing apoptosis without obvious immunotoxicity. PPI exhibited a remarkable hemolytic effect on rabbit erythrocytes (EC50 = 4.3 mu M), while it had no impact in mice. Conclusion Our study revealed that the PPI-sensitized chemotherapeutic effect, when used in safe doses, circumvents immunotoxic side effects of DOX in vivo; thus, helping future clinical research. |
| WOS记录号 | WOS:000741933200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74770]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, Xiang,Na, Xin,Zeng, Yueqin,et al. Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin[J]. MOLECULAR & CELLULAR TOXICOLOGY,2022,18(3):359-369. |
| APA | Zhu, Xiang.,Na, Xin.,Zeng, Yueqin.,Xu, Yangantai.,Chai, Dongya.,...&Zhou, Yiping.(2022).Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin.MOLECULAR & CELLULAR TOXICOLOGY,18(3),359-369. |
| MLA | Zhu, Xiang,et al."Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin".MOLECULAR & CELLULAR TOXICOLOGY 18.3(2022):359-369. |
入库方式： OAI收割
来源：昆明植物研究所
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