Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance
文献类型：期刊论文
| 作者 | Qin, Wanying; Zhang, Ting; Ge, Mingxia; Zhou, Huimin; Xu, Yuhui; Mu, Rongfang; Huang, Chaoguang; Liu, Daowei; Huang, Bangrui; Wang, Qian |
| 刊名 | JOURNAL OF ENDOCRINOLOGY
 |
| 出版日期 | 2022 |
| 卷号 | 254期号:3页码:151-165 |
| 关键词 | RACK1 bile acid glucose metabolism insulin sensitivity ENDOPLASMIC-RETICULUM STRESS C-KINASE 1 HEPATOCELLULAR-CARCINOMA STEROL 12-ALPHA-HYDROXYLASE DOWN-REGULATION ER STRESS KAPPA-B RECEPTOR ACTIVATION GROWTH |
| DOI | 10.1530/JOE-22-0076 |
| 英文摘要 | Receptor for activated C kinase 1 (RACK1) is a versatile protein involved in multiple biological processes. In a previous study by Zhao et al., hepatic RACK1 deletion in mice led to an inhibition of autophagy, blocked autophagy-dependent lipolysis, and caused steatosis. Using the same mouse model (RACK1(hep-/-)), we revealed new roles of RACK1 in maintaining bile acid homeostasis and hepatic glucose uptake, which further affected circulatory lipid and glucose levels. To be specific, even under hepatic steatosis, the plasma lipids were generally reduced in RACK1(hep-/-) mouse, which was due to the suppression of intestinal lipid absorption. Accordingly, a decrease in total bile acid level was found in RACK1(hep-/-) livers, gallbladders, and small intestine tissues, and specific decrease of 12-hydroxylated bile acids was detected by liquid chromatography-mass spectrometry. Consistently, reduced expression of CYP8B1 was found. A decrease in hepatic glycogen storage was also observed, which might be due to the inhibited glucose uptake by GLUT2 insufficiency. Interestingly, RACK1-KO-inducing hepatic steatosis did not raise insulin resistance (IR) nor IR-inducing factors like endoplasmic reticulum stress and inflammation. In summary, this study uncovers that hepatic RACK1 might be required in maintaining bile acid homeostasis and glucose uptake in hepatocytes. This study also provides an additional case of hepatic steatosis disassociation with insulin resistance. |
| WOS记录号 | WOS:000848359900002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74773]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Qin, Wanying,Zhang, Ting,Ge, Mingxia,et al. Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance[J]. JOURNAL OF ENDOCRINOLOGY,2022,254(3):151-165. |
| APA | Qin, Wanying.,Zhang, Ting.,Ge, Mingxia.,Zhou, Huimin.,Xu, Yuhui.,...&Xiong, Wenyong.(2022).Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance.JOURNAL OF ENDOCRINOLOGY,254(3),151-165. |
| MLA | Qin, Wanying,et al."Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance".JOURNAL OF ENDOCRINOLOGY 254.3(2022):151-165. |
入库方式： OAI收割
来源：昆明植物研究所
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