Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity
文献类型：期刊论文
| 作者 | Luo, Shuaibin; Zhang, Xuemei ; He, Kang; Zou, Juan; Geng, Chang-An
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| 刊名 | PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
 |
| 出版日期 | 2022 |
| 卷号 | 91期号:8页码:1809-1816 |
| 关键词 | Uncaria rhynchophylla triterpenoids antidiabetic effects PTP1B inhibitors ALKALOIDS |
| DOI | 10.32604/phyton.2022.020935 |
| 英文摘要 | Uncaria rhynchophylla (Gouteng) is a famous traditional Chinese medicine used for psychiatric and hypotensive purposes in China. In this study, the ethyl acetate (EtOAc) part of U. rhynchophylla was revealed with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Subsequent investigation on the EtOAc part yielded one new triterpenoid, 313-formyloxy-613,19a-dihydroxyurs-12-en-28-oic acid (1) and four known ones, 313,613,19a-trihydroxyurs-12-en-28-oic acid (2), 2-oxopomolic acid (3), 313,19a-dihydroxy-6-oxo-olean-12-en-28-oic acid (4) and sumaresinolic acid (5). The structure of compound 1 was determined by extensive HRESIMS, IR, 1D and 2D NMR spectroscopic analyses. Two ursane-type triterpenoids (2 and 3) showed selective inhibition on PTP1B with IC50 values of 48.2 and 178.7 yM. The enzyme kinetic study suggested that compounds 2 and 3 were mixtype inhibitors on PTP1B with Ki values of 15.6 and 132.5 yM. This investigation manifests the antidiabetic potency of U. rhynchophylla with triterpenoids as the active constituents. |
| WOS记录号 | WOS:000789076500005 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74790]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Luo, Shuaibin,Zhang, Xuemei,He, Kang,et al. Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity[J]. PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY,2022,91(8):1809-1816. |
| APA | Luo, Shuaibin,Zhang, Xuemei,He, Kang,Zou, Juan,&Geng, Chang-An.(2022).Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity.PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY,91(8),1809-1816. |
| MLA | Luo, Shuaibin,et al."Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity".PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY 91.8(2022):1809-1816. |
入库方式： OAI收割
来源：昆明植物研究所
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