Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities
文献类型：期刊论文
| 作者 | Shang,Chong; Ma,Yun-Bao; Wang,Yuan; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2023 |
| 卷号 | 46期号:9-10页码:782-794 |
| 关键词 | Artemisia mongolica Artemongolins A-K Sesquiterpenoid dimers Antihepatoma activity HEPATOCELLULAR-CARCINOMA LACTONE ARGYI |
| ISSN号 | 1976-3786 |
| DOI | 10.1007/s12272-023-01466-x |
| 英文摘要 | Artemongolins A-K (1-11), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1, 4, and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A-K (1-11) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluation against three human hepatoma cell lines demonstrated that the most active compounds 5 and 6 displayed inhibitory activity with IC50 values of 88.6 and 57.0 (HepG2), 59.1 and 26.4 (Huh7), and 67.5 and 32.5 (SK-Hep-1) mu M, respectively. |
| WOS记录号 | WOS:001075038900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74829]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Shang,Chong,Ma,Yun-Bao,Wang,Yuan,et al. Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities[J]. ARCHIVES OF PHARMACAL RESEARCH,2023,46(9-10):782-794. |
| APA | Shang,Chong,Ma,Yun-Bao,Wang,Yuan,He,Xiao-Feng,Li,Tian-Ze,&Chen,Ji-Jun.(2023).Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities.ARCHIVES OF PHARMACAL RESEARCH,46(9-10),782-794. |
| MLA | Shang,Chong,et al."Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities".ARCHIVES OF PHARMACAL RESEARCH 46.9-10(2023):782-794. |
入库方式： OAI收割
来源：昆明植物研究所
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