A natural biological adhesive from snail mucus for wound repair
文献类型：期刊论文
| 作者 | Deng, Tuo; Gao, Dongxiu; Song, Xuemei; Zhou, Zhipeng; Zhou, Lixiao; Tao, Maixian; Jiang, Zexiu; Yang, Lian; Luo, Lan; Zhou, Ankun |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2023 |
| 卷号 | 14期号:1页码:396 |
| 关键词 | FOOT GLYCOSAMINOGLYCANS OPPORTUNITIES POLARIZATION CHEMISTRY PROTEINS HELIX CARE |
| DOI | 10.1038/s41467-023-35907-4 |
| 英文摘要 | The discovery of natural adhesion phenomena andmechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs. |
| 学科主题 | Science & Technology - Other Topics |
| WOS记录号 | WOS:001170148000004 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74864]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Deng, Tuo,Gao, Dongxiu,Song, Xuemei,et al. A natural biological adhesive from snail mucus for wound repair[J]. NATURE COMMUNICATIONS,2023,14(1):396. |
| APA | Deng, Tuo.,Gao, Dongxiu.,Song, Xuemei.,Zhou, Zhipeng.,Zhou, Lixiao.,...&Wu, Mingyi.(2023).A natural biological adhesive from snail mucus for wound repair.NATURE COMMUNICATIONS,14(1),396. |
| MLA | Deng, Tuo,et al."A natural biological adhesive from snail mucus for wound repair".NATURE COMMUNICATIONS 14.1(2023):396. |
入库方式： OAI收割
来源：昆明植物研究所
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