Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia
文献类型：期刊论文
| 作者 | Hu,Jiadong; Qiu,Shi; Wang,Feiyan; Li,Qing; Xiang,Chun-Lei; Di,Peng; Wu,Ziding; Jiang,Rui; Li,Jinxing; Zeng,Zhen |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2023 |
| 卷号 | 14期号:1页码:4696 |
| 关键词 | CARNOSIC ACID PHYLOGENETIC ANALYSIS ARABIDOPSIS-THALIANA GENOME DUPLICATIONS STAMINAL EVOLUTION LAMIACEAE BIOSYNTHESIS TANSHINONES TOOL |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-023-40401-y |
| 英文摘要 | The genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, are specific to Salvia and exhibit taxonomic chemical diversity among lineages. To elucidate how ATD chemical diversity evolved, we carried out large-scale metabolic and phylogenetic analyses of 71 Salvia species, combined with enzyme function, ancestral sequence and chemical trait reconstruction, and comparative genomics experiments. This integrated approach showed that the lineage-wide ATD diversities in Salvia were induced by differences in the oxidation of the terpenoid skeleton at C-20, which was caused by the functional divergence of the cytochrome P450 subfamily CYP76AK. These findings present a unique pattern of chemical diversity in plants that was shaped by the loss of enzyme activity and associated catalytic pathways. Functional divergence of CYP76AK subfamily, accompanied by oxidation variations at C-20, leads to diverse abietane-type diterpenoids in Salvia species. Enzyme activity loss contributes to this unique chemical diversity within the lineage. |
| WOS记录号 | WOS:001042606700016 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74868]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Hu,Jiadong,Qiu,Shi,Wang,Feiyan,et al. Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia[J]. NATURE COMMUNICATIONS,2023,14(1):4696. |
| APA | Hu,Jiadong.,Qiu,Shi.,Wang,Feiyan.,Li,Qing.,Xiang,Chun-Lei.,...&Chen,Wansheng.(2023).Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia.NATURE COMMUNICATIONS,14(1),4696. |
| MLA | Hu,Jiadong,et al."Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia".NATURE COMMUNICATIONS 14.1(2023):4696. |
入库方式： OAI收割
来源：昆明植物研究所
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