Discovery of nontriterpenoids from the rot roots of Panax notoginseng with cytotoxicity and their molecular docking study and experimental validation
文献类型：期刊论文
| 作者 | Shang,Jia-Huan; Qiao,Yi-Jun; Zhu,Hong-Tao; Wang,Dong ; Yang,Chong-Ren; Zhang,Ying-Jun
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2023 |
| 卷号 | 13期号:16页码:11037-11043 |
| 关键词 | THERAPY |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/d3ra00720k |
| 英文摘要 | Panax notoginseng (PN) is a well-known traditional Chinese medicine, with dammarane-type triterpenoid saponins characterized as major component and active ingredients, together with amino acids, flavonoids, polysaccharides, and polyacetylenes. The roots of PN are susceptible to root rot disease, which causes a huge loss and changes in the chemical components of this precious resource. In this study, sub-fractions of rot PN root extracts were preliminarily found to have admirable cytotoxicity on two human cancer cells. Further bioassay-guided isolation discovered nine new non-triterpenoids, including two novel N-methylacetamido-1-oxotetrahydropyrimidine alkaloids (1, 2), five 2H-furanones or 2H-pyranones (3-7), and two polyacetylenic alcohols (8, 9). Their structures were illuminated by extensive spectroscopic data, calculated ECD, and X-ray diffraction analysis. Among them, 3-7 were considered to be transformed from panaxatriol through the intermediates (8, 9). The new alkaloids (1, 2) displayed noteworthy cytotoxicity against five human cancer cells with IC50 values ranging from 14 to 24 mu M. In silico target prediction and molecular docking studies showed that 1 and 2 may interact with EGFR, and were verified by the experimental inhibitory effect on EGFR tyrosine kinase. |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:000964730700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74882]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Shang,Jia-Huan,Qiao,Yi-Jun,Zhu,Hong-Tao,et al. Discovery of nontriterpenoids from the rot roots of Panax notoginseng with cytotoxicity and their molecular docking study and experimental validation[J]. RSC ADVANCES,2023,13(16):11037-11043. |
| APA | Shang,Jia-Huan,Qiao,Yi-Jun,Zhu,Hong-Tao,Wang,Dong,Yang,Chong-Ren,&Zhang,Ying-Jun.(2023).Discovery of nontriterpenoids from the rot roots of Panax notoginseng with cytotoxicity and their molecular docking study and experimental validation.RSC ADVANCES,13(16),11037-11043. |
| MLA | Shang,Jia-Huan,et al."Discovery of nontriterpenoids from the rot roots of Panax notoginseng with cytotoxicity and their molecular docking study and experimental validation".RSC ADVANCES 13.16(2023):11037-11043. |
入库方式： OAI收割
来源：昆明植物研究所
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