Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)
文献类型：期刊论文
| 作者 | Meurer,Mariane; Felisbino,Fabiula; Mueller,Fabiana B.; Somensi,Lincon B.; Cury,Benhur J.; Jeronimo,Daniele T.; Venzon,Larissa; Franca,Tauani C. S.; Mariott,Mariha; Santos,Ana C. |
| 刊名 | ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
 |
| 出版日期 | 2023 |
| 卷号 | 95页码:e20220427 |
| 关键词 | lutein gastric ulcer oxidative stress phytotherapy H pylori GASTRIC-MUCOSAL LESIONS METHANOLIC EXTRACT OXIDATIVE STRESS NITRIC-OXIDE ULCER PROSTAGLANDINS ANTIOXIDANT BARK SULFHYDRYLS FRUITS |
| ISSN号 | 1678-2690 |
| DOI | 10.1590/0001-3765202320220427 |
| 英文摘要 | The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol-or indomethacininduced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, & alpha;2 adrenergic receptors, and prostaglandins, but not antisecretory or anti -H. pylori properties. |
| WOS记录号 | WOS:001049037000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74960]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Meurer,Mariane,Felisbino,Fabiula,Mueller,Fabiana B.,et al. Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)[J]. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS,2023,95:e20220427. |
| APA | Meurer,Mariane.,Felisbino,Fabiula.,Mueller,Fabiana B..,Somensi,Lincon B..,Cury,Benhur J..,...&Silva,Luisa M..(2023).Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.).ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS,95,e20220427. |
| MLA | Meurer,Mariane,et al."Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)".ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS 95(2023):e20220427. |
入库方式： OAI收割
来源：昆明植物研究所
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