Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta
文献类型：期刊论文
| 作者 | Li,Jinliang; Li,Fengchao; Wu,Guoxing; Gui,Furong; Li,Hongmei; Xu,Lili; Hao,Xiaojiang ; Zhao,Yuhan; Ding,Xiao; Qin,Xiaoping
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| 刊名 | FRONTIERS IN PLANT SCIENCE
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| 出版日期 | 2023 |
| 卷号 | 14页码:1074184 |
| 关键词 | Laggera pterodonta sesquiterpenes acetylcholinesterase enzyme kinetics toxic effects DERIVATIVES FLAVONOIDS TERPENOIDS MECHANISM |
| DOI | 10.3389/fpls.2023.1074184 |
| 英文摘要 | Plant-derived natural products are important resources for pesticide discovery. Acetylcholinesterase (AChE) is a well-validated pesticide target, and inhibiting AChE proves fatal for insects. Recent studies have shown that the potential of various sesquiterpenoids as AChE inhibitors. However, few studies have been conducted with eudesmane-type sesquiterpenes with AChE inhibitory effects. Therefore, in this research, we isolated two new sesquiterpenes, laggeranines A (1) and B (2), along with six known eudesmane-type sesquiterpenes (3-8) from Laggera pterodonta, and characterized their structures and the inhibitory effect they exerted on AChE. The results showed that these compounds had certain inhibitory effects on AChE in a dose-dependent manner, of which compound 5 had the best inhibitory effect with IC50 of 437.33 +/- 8.33 mM. As revealed by the Lineweaver-Burk and Dixon plots, compound 5 was observed to suppress AChE activity reversibly and competitively. Furthermore, all compounds exhibited certain toxicity levels on C. elegans. Meanwhile, these compounds had good ADMET properties. These results are significant for the discovery of new AChE targeting compounds, and also enrich the bioactivity activity repertoire of L. pterodonta. |
| 学科主题 | Plant Sciences |
| WOS记录号 | WOS:000937438200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74971]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Li,Jinliang,Li,Fengchao,Wu,Guoxing,et al. Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta[J]. FRONTIERS IN PLANT SCIENCE,2023,14:1074184. |
| APA | Li,Jinliang.,Li,Fengchao.,Wu,Guoxing.,Gui,Furong.,Li,Hongmei.,...&Qin,Xiaoping.(2023).Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta.FRONTIERS IN PLANT SCIENCE,14,1074184. |
| MLA | Li,Jinliang,et al."Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta".FRONTIERS IN PLANT SCIENCE 14(2023):1074184. |
入库方式： OAI收割
来源：昆明植物研究所
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