Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology
文献类型：期刊论文
| 作者 | Yan,Ying; Zhou,Qi; Ran,Xiaoqian; Lu,Qingyun; Zhang,Cuishan; Peng,Mingyou; Tang,Lei; Luo,Rongcan; Di,Yingtong ; Hao,Xiaojiang
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2023 |
| 卷号 | 24期号:2页码:1088 |
| 关键词 | euphjatrophane Euphorbia peplus jatrophane diterpenoid autophagy Tau pathology UBIQUITIN-PROTEASOME SYSTEM MULTIDRUG-RESISTANCE BIOLOGICAL-ACTIVITY ALZHEIMERS-DISEASE MODULATORS CELLS |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms24021088 |
| 英文摘要 | Ten jatrophane diterpenoids were isolated from the whole plant Euphorbia peplus Linn. including seven new ones, named euphjatrophanes A-G (labeled compounds 1, 2, 4-8). Their structures were elucidated with a combination of spectroscopic and single-crystal X-ray crystallography, enabling the identification of compounds 3, 9, and 10 as the previously published euphpepluones G, K, and L, respectively. All compounds were evaluated for their bioactivity with flow cytometry in assays of autophagic flux in HM Cherry-GFP-LC3 (human microglia cells stably expressing the tandem monomeric mCherry-GFP-tagged LC3) cells. Euphpepluone K (9) significantly activated autophagic flux, an effect that was verified with confocal analysis. Moreover, cellular assays showed that euphpepluone K (9) induced autophagy and inhibited Tau pathology. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000917637200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75011]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yan,Ying,Zhou,Qi,Ran,Xiaoqian,et al. Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(2):1088. |
| APA | Yan,Ying.,Zhou,Qi.,Ran,Xiaoqian.,Lu,Qingyun.,Zhang,Cuishan.,...&Hao,Xiaojiang.(2023).Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(2),1088. |
| MLA | Yan,Ying,et al."Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.2(2023):1088. |
入库方式： OAI收割
来源：昆明植物研究所
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