New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)
文献类型：期刊论文
| 作者 | Li,Sheng; Han,Ling-Ling; Huang,Ke-Pu; Ma,Ye-Han; Guo,Ling-Li; Guo,Yarong; Ran,Xiaoqian; Yao,Yong-Gang; Hao,Xiao-Jiang ; Luo,Rongcan
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2023 |
| 卷号 | 24期号:2页码:1487 |
| 关键词 | Tabernaemontana crassa monoterpenoid indole alkaloids A beta 42 phospho-tau (Thr217) Alzheimer's disease ALZHEIMERS-DISEASE BISINDOLE ALKALOIDS CDK5 GEMFIBROZIL PREVENTION ALGORITHM AUTOPHAGY MODELS PLANTS MOUSE |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms24021487 |
| 英文摘要 | Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A-C (1-3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan-ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1-3 all reduce A beta 42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer's disease [AD] associated with BACE1-, NCSTN-, GSK3 beta-, and CDK5-mediated pathways, suggesting these alkaloids' potential against AD. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000919613400001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75013]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Li,Sheng,Han,Ling-Ling,Huang,Ke-Pu,et al. New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(2):1487. |
| APA | Li,Sheng.,Han,Ling-Ling.,Huang,Ke-Pu.,Ma,Ye-Han.,Guo,Ling-Li.,...&Zhang,Yu.(2023).New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(2),1487. |
| MLA | Li,Sheng,et al."New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.2(2023):1487. |
入库方式： OAI收割
来源：昆明植物研究所
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