Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling
文献类型：期刊论文
| 作者 | Xu,Xinglian; Deng,Lulu; Tang,Yaling; Li,Jiang; Zhong,Ting; Hao,Xiaojiang ; Fan,Yanhua; Mu,Shuzhen
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2023 |
| 卷号 | 24期号:9页码:8113 |
| 关键词 | leukemia sanguinarine c-MET MAPK PI3K/mTOR STAT3 MET |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms24098113 |
| 英文摘要 | Sanguinarine (1) is a natural product with significant pharmacological effects. However, the application of sanguinarine has been limited due to its toxic side effects and a lack of clarity regarding its molecular mechanisms. To reduce the toxic side effects of sanguinarine, its cyanide derivative (1a) was first designed and synthesized in our previous research. In this study, we confirmed that 1a presents lower toxicity than sanguinarine but shows comparable anti-leukemia activity. Further biological studies using RNA-seq, lentiviral transfection, Western blotting, and flow cytometry analysis first revealed that both compounds 1 and 1a inhibited the proliferation and induced the apoptosis of leukemic cells by regulating the transcription of c-MET and then suppressing downstream pathways, including the MAPK, PI3K/AKT and JAK/STAT pathways. Collectively, the data indicate that 1a, as a potential anti-leukemia lead compound regulating c-MET transcription, exhibits better safety than 1 while maintaining cytostatic activity through the same mechanism as 1. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000987326400001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75015]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Xu,Xinglian,Deng,Lulu,Tang,Yaling,et al. Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(9):8113. |
| APA | Xu,Xinglian.,Deng,Lulu.,Tang,Yaling.,Li,Jiang.,Zhong,Ting.,...&Mu,Shuzhen.(2023).Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(9),8113. |
| MLA | Xu,Xinglian,et al."Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.9(2023):8113. |
入库方式： OAI收割
来源：昆明植物研究所
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