Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect
文献类型：期刊论文
| 作者 | Cai,Min; Bai,Xiao-Lin; Zang,Hao-Jing; Tang,Xiao-Han; Yan,Ying; Wan,Jia-Jia; Peng,Min-You; Liang,Hong; Liu,Lin; Guo,Feng |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2023 |
| 卷号 | 24期号:22页码:16196 |
| 关键词 | Harrisonia perforata quassinoid simarubaceae neuroprotection PC12 cells PINK1(B9) flies PROMISING BIOLOGICAL-ACTIVITY UNPRECEDENTED QUASSINOIDS |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms242216196 |
| 英文摘要 | Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (1-7), were isolated from twigs of Harrisonia perforata. Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Drosophila Parkinson's disease model of PINK1(B9). Perforalactones G and I (2 and 4) showed a 10-15% increase in cell viability of the model cells at 50 mu M, while compounds 2 and 4 (100 mu M) significantly improved the climbing ability of PINK1(B9) flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies. |
| WOS记录号 | WOS:001114632500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75018]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Cai,Min,Bai,Xiao-Lin,Zang,Hao-Jing,et al. Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(22):16196. |
| APA | Cai,Min.,Bai,Xiao-Lin.,Zang,Hao-Jing.,Tang,Xiao-Han.,Yan,Ying.,...&Hao,Xiao-Jiang.(2023).Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(22),16196. |
| MLA | Cai,Min,et al."Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.22(2023):16196. |
入库方式： OAI收割
来源：昆明植物研究所
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