Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima
文献类型：期刊论文
| 作者 | Meng,Qian-Qian; Tong,Shun-Yao; Peng,Xing-Rong; Zhao,Yu-Qing; Li,Zheng-Hui; Chen,He-Ping; Liu,Ji-Kai |
| 刊名 | MOLECULES
 |
| 出版日期 | 2023 |
| 卷号 | 28期号:6页码:2705 |
| ISSN号 | 1420-3049 |
| 关键词 | Marsdenia tenacissima (Roxb ) moon asclepiadaceae pregnane glycosides structural elucidation nitric oxide production inhibition STEMS |
| DOI | 10.3390/molecules28062705 |
| 英文摘要 | The ethnobotanical plant Marsdenia tenacissima has been used for hundreds of years for Dai people in Yunnan Province, China. Previously, chemical investigations on this plant have revealed that pregnane glycosides were the main biological constituents. Nine new pregnane glycosides, marsdeosides A-I (1-9), were isolated from cultivated dried stems of the medicinal plant Marsdenia tenacissima in this study. The structures were analyzed by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and IR spectroscopic analysis. The absolute configurations of the sugar moieties were identified by comparing the R-f values and specific optical rotations with those of the commercially available standard samples and the data reported in the literature. Marsdeosides A (1) featured an unusual 8,14-seco-pregnane skeleton. Compounds 1, 8, and 9 showed activity against nitric oxide production in lipopolysaccharide-activated macrophage RAW264.7, with IC50 values of 37.5, 38.8, and 42.8 mu M (L-NMMA was used as a positive control, IC50 39.3 mu M), respectively. This study puts the knowledge of the chemical profile of the botanical plant M. tenacissima one step forward and, thereby, promotes the sustainable utilization of the resources of traditional folk medicinal plants. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000958792300001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75037]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Meng,Qian-Qian,Tong,Shun-Yao,Peng,Xing-Rong,et al. Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima[J]. MOLECULES,2023,28(6):2705. |
| APA | Meng,Qian-Qian.,Tong,Shun-Yao.,Peng,Xing-Rong.,Zhao,Yu-Qing.,Li,Zheng-Hui.,...&Liu,Ji-Kai.(2023).Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima.MOLECULES,28(6),2705. |
| MLA | Meng,Qian-Qian,et al."Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima".MOLECULES 28.6(2023):2705. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。