New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
文献类型：期刊论文
| 作者 | Meng,Qianqian; Tong,Shunyao; Zhao,Yuqing; Peng,Xingrong; Li,Zhenghui; Feng,Tao; Liu,Jikai |
| 刊名 | MOLECULES
 |
| 出版日期 | 2023 |
| 卷号 | 28期号:12页码:4590 |
| 关键词 | Paeonia suffruticosa benzofuranones cytotoxicity NO production inhibition MOUTAN CORTEX SESQUITERPENE CONSTITUENTS |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules28124590 |
| 英文摘要 | The Paeonia suffruticosa, known as 'Feng Dan', has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, paeobenzofuranones A-E (1-5), were characterized. Their structures were determined using spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds 2, 4, and 5 showed cytotoxicity against three human cancer cell lines, with IC50 values ranging from 6.7 to 25.1 & mu;M. Compounds 1 and 2 showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of P. suffruticosa are reported for the first time in this paper. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:001017545500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75038]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Meng,Qianqian,Tong,Shunyao,Zhao,Yuqing,et al. New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition[J]. MOLECULES,2023,28(12):4590. |
| APA | Meng,Qianqian.,Tong,Shunyao.,Zhao,Yuqing.,Peng,Xingrong.,Li,Zhenghui.,...&Liu,Jikai.(2023).New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition.MOLECULES,28(12),4590. |
| MLA | Meng,Qianqian,et al."New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition".MOLECULES 28.12(2023):4590. |
入库方式： OAI收割
来源：昆明植物研究所
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