Palladium-Catalyzed Directed Carbon-Carbon Bond Activation of Aryl Nitriles for Cyano Transfer
文献类型：期刊论文
| 作者 | Tan, Lin2,5; Pan, Yang1; Zeng, Qing-Ying2,5; Wang, Zhen-Yu4; Xu, Hui4; Dai, Hui-Xiong1,2,3,4,5
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2024-03-07 |
| 卷号 | 26期号:11页码:2260-2265 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c00429 |
| 通讯作者 | Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | Herein, we report the C-H cyanation of indoles via a palladium-catalyzed directed C-CN activation reaction using aryl nitrile as a cyano source. The employment of the phenoxy-oriented group is the key to the cleavage of the C-CN bond. This protocol features a broad substrate scope, good efficiency, and high regioselectivity. Furthermore, the practical application of this protocol was showcased in the late-stage functionalization and synthesis of indole derivatives, which were derived from drugs and natural products, through the process of cyanation. |
| WOS关键词 | IN-VITRO ; INDOLES ; FUNCTIONALIZATION ; CYANATION ; CLEAVAGE |
| 资助项目 | National Natural Science Foundation of China ; Shanghai Institute of Materia Medica ; Chinese Academy of Sciences[22171276] ; Chinese Academy of Sciences[21920102003] ; National Natural Science Foundation of China[21ZR1475400] ; National Natural Science Foundation of China[23ZR1474400] ; Science and Technology Commission of Shanghai Municipality |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001181185900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310127]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dai, Hui-Xiong |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Media, Nanjing 210023, Jiangsu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Lin,Pan, Yang,Zeng, Qing-Ying,et al. Palladium-Catalyzed Directed Carbon-Carbon Bond Activation of Aryl Nitriles for Cyano Transfer[J]. ORGANIC LETTERS,2024,26(11):2260-2265. |
| APA | Tan, Lin,Pan, Yang,Zeng, Qing-Ying,Wang, Zhen-Yu,Xu, Hui,&Dai, Hui-Xiong.(2024).Palladium-Catalyzed Directed Carbon-Carbon Bond Activation of Aryl Nitriles for Cyano Transfer.ORGANIC LETTERS,26(11),2260-2265. |
| MLA | Tan, Lin,et al."Palladium-Catalyzed Directed Carbon-Carbon Bond Activation of Aryl Nitriles for Cyano Transfer".ORGANIC LETTERS 26.11(2024):2260-2265. |
入库方式： OAI收割
来源：上海药物研究所
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