A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide
文献类型：期刊论文
| 作者 | Hu, Jingxin2; Wang, Ruiya2; Liao, Wantao2; Hu, Jinhui2; Li, Lanqing2; Cheng, Zhen1; Chen, Wen- Hua2 |
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2024-04-01 |
| 卷号 | 1296页码:12 |
| 关键词 | Fluorescent probe Donor-acceptor type Nitric oxide Colorimetric detection Bioimaging |
| ISSN号 | 0003-2670 |
| DOI | 10.1016/j.aca.2024.342333 |
| 通讯作者 | Li, Lanqing(lilanqing91@163.com) ; Cheng, Zhen(zcheng@simm.ac.cn) ; Chen, Wen- Hua(zcheng@simm.ac.cn) |
| 英文摘要 | Nitric oxide (NO) plays an essential role in regulating various physiological and pathological processes. This has spurred various efforts to develop feasible methods for the detection of NO. Herein we designed and synthesized a novel donor -acceptor fluorescent probe Car -NO for the selective and specific detection of NO. Reaction of CarNO with NO generated a new donor -acceptor structure with strong intramolecular charge transfer (ICT) effect, and led to remarkable chromogenic change from yellow to blue and dramatic fluorescence quenching. Car -NO exhibited high selectivity, excellent sensitivity, and rapid response for the detection of NO. In addition, the nanoparticles prepared from Car -NO (i.e., Car -NO NPs) showed strong NIR emission and high selectivity/ sensitivity. Car -NO NPs was successfully employed to image both endogenous and exogenous NO in HeLa and RAW 264.7 cells. The present findings reveal that Car -NO is a promising probe for the detection and bioimaging of NO. |
| WOS关键词 | SELECTIVE DETECTION ; INFLAMMATION |
| 资助项目 | Jiangmen City Science and Technology Basic Research Project[2022JC01012] ; Department of Education of Guangdong Province[2022KQNCX092] ; Foundation of Guangdong Basic and Applied Basic Research[2022A1515110134] ; Wuyi University[2021AL026] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001183792600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310139]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Lanqing; Cheng, Zhen; Chen, Wen- Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Jingxin,Wang, Ruiya,Liao, Wantao,et al. A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide[J]. ANALYTICA CHIMICA ACTA,2024,1296:12. |
| APA | Hu, Jingxin.,Wang, Ruiya.,Liao, Wantao.,Hu, Jinhui.,Li, Lanqing.,...&Chen, Wen- Hua.(2024).A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide.ANALYTICA CHIMICA ACTA,1296,12. |
| MLA | Hu, Jingxin,et al."A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide".ANALYTICA CHIMICA ACTA 1296(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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