Chemical and biosynthetic potential of Penicillium shentong XL-F41
文献类型：期刊论文
| 作者 | Zou, Ran2,3; Li, Xin3; Chen, Xiaochen3; Guo, Yue-Wei1,3 ; Xu, Baofu1,3
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| 刊名 | BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2024-03-15 |
| 卷号 | 20页码:597-606 |
| 关键词 | genome analysis indole terpene alkaloid natural products Penicillium structure elucidation |
| ISSN号 | 1860-5397 |
| DOI | 10.3762/bjoc.20.52 |
| 通讯作者 | Xu, Baofu(bfxu@simm.ac.cn) |
| 英文摘要 | Penicillium strains are renowned for producing diverse secondary metabolites with unique structures and promising bioactivities. Our chemical investigations, accompanied by fermentation media optimization, of a newly isolated fungus, Penicillium shentong XL -F41, led to the isolation of twelve compounds. Among these are two novel indole terpene alkaloids, shentonins A and B (1 and 2), and a new fatty acid 3. Shentonin A (1) is distinguished by an unusual methyl modification at the oxygen atom of the typical succinimide ring, a feature not seen in the structurally similar brocaeloid D. Additionally, shentonin A (1) exhibits a cis relationship between H-3 and H-4, as opposed to the trans configuration in brocaeloid D, suggesting a divergent enzymatic ring -expansion process in their respective fungi. Both shentonins A (1) and B (2) also feature a reduction of a carbonyl to a hydroxy group within the succinimide ring. All isolated compounds were subjected to antimicrobial evaluations, and compound 12 was found to have moderate inhibitory activity against Candia albicans. Moreover, genome sequencing of Penicillium shentong XL -F41 uncovered abundant silent biosynthetic gene clusters, indicating the need for future efforts to activate these clusters and unlock the full chemical potential of the fungus. |
| WOS关键词 | DEHYDROCURVULARIN ; POLYKETIDE ; CURVULARIN ; ALKALOIDS ; FUNGUS ; ACID |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001186867800001 |
| 出版者 | BEILSTEIN-INSTITUT |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310148]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Baofu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Ran,Li, Xin,Chen, Xiaochen,et al. Chemical and biosynthetic potential of Penicillium shentong XL-F41[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2024,20:597-606. |
| APA | Zou, Ran,Li, Xin,Chen, Xiaochen,Guo, Yue-Wei,&Xu, Baofu.(2024).Chemical and biosynthetic potential of Penicillium shentong XL-F41.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,20,597-606. |
| MLA | Zou, Ran,et al."Chemical and biosynthetic potential of Penicillium shentong XL-F41".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 20(2024):597-606. |
入库方式： OAI收割
来源：上海药物研究所
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