Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement
文献类型：期刊论文
| 作者 | Shen, Huan4,5; Pan, Li3; Ning, Keke3; Fang, Yuefei5; Muhitdinov, Bahtiyor2; Liu, Ergang5; Huang, Yongzhuo1,3,4,5
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| 刊名 | JOURNAL OF NANOBIOTECHNOLOGY
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| 出版日期 | 2024-03-17 |
| 卷号 | 22期号:1页码:13 |
| 关键词 | Asiatic acid Inclusion cocrystal Spring-and-hover model Lung targeting delivery Acute lung injury |
| DOI | 10.1186/s12951-024-02387-7 |
| 通讯作者 | Liu, Ergang(liuergang@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | BackgroundAcute lung injury (ALI) is a fatal respiratory disease caused by overreactive immune reactions (e.g., SARS-CoV-2 infection), with a high mortality rate. Its treatment is often compromised by inefficient drug delivery barriers and insufficient potency of the currently used drugs. Therefore, developing a highly effective lung-targeted drug delivery strategy is a pressing clinical need.ResultsIn this study, the micro-sized inclusion cocrystal of asiatic acid/gamma-cyclodextrin (AA/gamma CD, with a stoichiometry molar ratio of 2:3 and a mean size of 1.8 mu m) was prepared for ALI treatment. The dissolution behavior of the AA/gamma CD inclusion cocrystals followed a "spring-and-hover" model, which meaned that AA/gamma CD could dissolve from the cocrystal in an inclusion complex form, thereby promoting a significantly improved water solubility (nine times higher than free AA). This made the cyclodextrin-based inclusion cocrystals an effective solid form for enhanced drug absorption and delivery efficiency. The biodistribution experiments demonstrated AA/gamma CD accumulated predominantly in the lung (Cmax = 50 mu g/g) after systemic administration due to the micron size-mediated passive targeting effect. The AA/gamma CD group showed an enhanced anti-inflammatory therapeutic effect, as evidenced by reduced levels of pro-inflammatory cytokines in the lung and bronchoalveolar lavage fluids (BALF). Histological examination confirmed that AA/gamma CD effectively inhibited inflammation reactions.ConclusionThe micro-sized inclusion cocrystals AA/gamma CD were successfully delivered into the lungs by pulmonary administration and had a significant therapeutic effect on ALI. |
| WOS关键词 | SOLUBILITY |
| 资助项目 | National Outstanding Youth Science Fund Project of National Natural Science Foundation of China ; Shanghai Advanced Research Institute |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001186153900001 |
| 出版者 | BMC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310163]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Ergang; Huang, Yongzhuo |
| 作者单位 | 1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China 2.Uzbek Acad Sci, Inst Bioorgan Chem, 83 M Ulughbek St, Tashkent 100125, Uzbekistan 3.Zunyi Med Univ, Sch Pharm, Zunyi 563003, Peoples R China 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Huan,Pan, Li,Ning, Keke,et al. Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement[J]. JOURNAL OF NANOBIOTECHNOLOGY,2024,22(1):13. |
| APA | Shen, Huan.,Pan, Li.,Ning, Keke.,Fang, Yuefei.,Muhitdinov, Bahtiyor.,...&Huang, Yongzhuo.(2024).Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement.JOURNAL OF NANOBIOTECHNOLOGY,22(1),13. |
| MLA | Shen, Huan,et al."Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement".JOURNAL OF NANOBIOTECHNOLOGY 22.1(2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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