Composition analysis of Compound Shenhua Tablet, a seven-herb Chinese medicine for IgA nephropathy: evaluation of analyte-capacity of the assays
文献类型：期刊论文
| 作者 | Zhang, Haiyan6; Wang, Qiuyue5,6; Wang, Jianan4,5; Zhang, Sichao5,6; Jia, Weiwei5; He, Ning5; Xia, Xiaoyan5; Wang, Ting5; Lai, Liyu4,5; Li, Jiaying5 |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2024-02-01 |
| 卷号 | 22期号:2页码:178-192 |
| 关键词 | Compound Shenhua Tablet Composition analysis Analyte-capacity |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(24)60553-4 |
| 通讯作者 | Chen, Xiangmei(xmchen301@126.com) ; Yang, Junling(yangjl@simm.ac.cn) ; Li, Chuan(chli@simm.ac.cn) |
| 英文摘要 | Compound Shenhua Tablet, a medicine comprising seven herbs, is employed in treating IgA nephropathy. This study aimed to meticulously analyze its chemical composition. Based on a list of candidate compounds, identified through extensive literature review pertinent to the tablet's herbal components, the composition analysis entailed the systematic identification, characterization, and quantification of the constituents. The analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was evaluated. The identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents' daily doses. A total of 283 constituents, classified into 12 distinct categories, were identified and characterized in the Compound Shenhua Tablet. These constituents exhibited content levels of 1-10 982 mu g center dot g-1, with daily doses of 0.01-395 mu mol center dot d-1. The predominant constituents, with daily doses of >= 10 mu mol center dot d-1, include nine organic acids (citric acid, quinic acid, chlorogenic acid, cryptochlorogenic acid, gallic acid, neochlorogenic acid, isochlorogenic acid C, isochlorogenic acid B, and linoleic acid), five iridoids (specnuezhenide, nuezhenoside G13, nuezhenidic acid, secoxyloganin, and secologanoside), two monoterpene glycosides (paeoniflorin and albiflorin), a sesquiterpenoid (curzerenone), a triterpenoid (oleanolic acid), and a phenylethanoid (salidroside). Additionally, there were 83, 126, and 55 constituents detected in the medicine with daily doses of 1-10, 0.1-1, and 0.01-0.1 mu mol center dot d-1, respectively. The combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the medicine. This comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine. |
| WOS关键词 | XUEBIJING INJECTION ; RADIX ASTRAGALI ; GALLIC ACID ; DISPOSITION ; RATS ; PHARMACOKINETICS ; CATECHOLS |
| 资助项目 | National Natur-al Science Foundation of China[82192912] ; National Natur-al Science Foundation of China[82074273] ; Innovation Team and Talents Cultivation Program of National Ad-ministration of Traditional Chinese Medicine[ZYYCXTD-C-202009] ; Program of State Key Laboratory of Drug Research[SIMM2103ZZ-06] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001188084400001 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310166]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Xiangmei; Yang, Junling; Li, Chuan |
| 作者单位 | 1.Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China 2.Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, Natl Key Lab Kidney Dis, Beijing Key Lab Kidney Dis Res,Dept Nephrol,Med Ct, Beijing 100853, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 5.Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 301617, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Haiyan,Wang, Qiuyue,Wang, Jianan,et al. Composition analysis of Compound Shenhua Tablet, a seven-herb Chinese medicine for IgA nephropathy: evaluation of analyte-capacity of the assays[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2024,22(2):178-192. |
| APA | Zhang, Haiyan.,Wang, Qiuyue.,Wang, Jianan.,Zhang, Sichao.,Jia, Weiwei.,...&Li, Chuan.(2024).Composition analysis of Compound Shenhua Tablet, a seven-herb Chinese medicine for IgA nephropathy: evaluation of analyte-capacity of the assays.CHINESE JOURNAL OF NATURAL MEDICINES,22(2),178-192. |
| MLA | Zhang, Haiyan,et al."Composition analysis of Compound Shenhua Tablet, a seven-herb Chinese medicine for IgA nephropathy: evaluation of analyte-capacity of the assays".CHINESE JOURNAL OF NATURAL MEDICINES 22.2(2024):178-192. |
入库方式： OAI收割
来源：上海药物研究所
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