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PRDX2 deficiency increases MCD-induced nonalcoholic steatohepatitis in female mice

文献类型：期刊论文

作者Zhang, Mengqi3,4; Shi, Xiaofeng3,4; Tang, Minglei3,4; Yin, Wen3,4; Luo, Cheng2; Xie, Xiangyang1,3,4
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2024-03-15
卷号701页码:6
关键词PRDX2 NASH Oxidative stress Inflammation NF-kappa B
ISSN号0006-291X
DOI10.1016/j.bbrc.2024.149589
通讯作者Xie, Xiangyang(xyxie@tmu.edu.cn)
英文摘要Objective: To evaluate the role of PRDX2 in nonalcoholic steatohepatitis (NASH). Methods: NASH was induced in wild-type (WT) mice and liver-specific PRDX2 knockout (PRDX2 LKO) mice that were fed a methionine-choline deficient diet (MCD) for 5 weeks. Assessments of PRDX2 LKO's impact on the pathogenesis of NASH include histological analyses, quantitative PCR (q-PCR), western blotting (WB), and RNA sequencing (RNA-Seq). Results: PRDX2 LKO mice exhibited a significant increase in hepatic lipid accumulation and inflammation compared to WT mice after MCD feeding. PRDX2 KO markedly elevated circulating levels of aspartate aminotransferase (AST) and the pro-inflammatory signaling pathways within the liver. There was a notable increase in the activities of signal transducer and activator of transcription 1 (STAT1) and nuclear factor kappa B (NF-kappa B). We also found that PRDX2 KO significantly increased the extent of lipid peroxidation in the liver, most likely owing to the impaired peroxidase activity of PRDX2. Of interest, these findings were observed only in MCD-fed female mice, suggesting the sexual dimorphism of PRDX2 KO in MCD-induced NASH. Conclusion: PRDX2 deficiency increases MCD-induced NASH in female mice, suggesting a protective role for PRDX2.
WOS关键词LIVER ; NASH ; INFLAMMATION ; STEATOSIS ; CANCER ; CELLS
资助项目Tianjin Municipal Science and Technology Commission[20JCJQJC00240]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:001181807100001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/310169]  
专题中国科学院上海药物研究所
通讯作者Xie, Xiangyang
作者单位1.6 North Huanrui Rd, Tianjin 300134, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
3.Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin 300134, Peoples R China
4.Tianjin Med Univ, Chu Hsien I Mem Hosp, NHC Key Lab Hormones & Dev, Tianjin Key Lab Metab Dis, Tianjin 300134, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Mengqi,Shi, Xiaofeng,Tang, Minglei,et al. PRDX2 deficiency increases MCD-induced nonalcoholic steatohepatitis in female mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2024,701:6.
APA Zhang, Mengqi,Shi, Xiaofeng,Tang, Minglei,Yin, Wen,Luo, Cheng,&Xie, Xiangyang.(2024).PRDX2 deficiency increases MCD-induced nonalcoholic steatohepatitis in female mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,701,6.
MLA Zhang, Mengqi,et al."PRDX2 deficiency increases MCD-induced nonalcoholic steatohepatitis in female mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 701(2024):6.

入库方式： OAI收割

来源：上海药物研究所

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