Palladium(II)-Catalyzed Heck Coupling: Direct Stereoselective Synthesis of C-Aryl Glycosides from Nonactivated Glycals and Thianthrenium Salts
文献类型：期刊论文
| 作者 | Wei, Xinxin3,4; Zeng, Mingjie2,3; Li, Yazhou3; Wang, Dechuan4; Wang, Jiang1,3 ; Liu, Hong2,3
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2024-03-18 |
| 页码 | 5 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c00654 |
| 通讯作者 | Wang, Dechuan(wdc@cpu.edu.cn) ; Wang, Jiang(jwang@lglab.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | Here, we report an efficient Pd(II)-catalyzed Heck coupling reaction utilizing modular and readily available thianthrenium salts. The tunability and ease of thianthrenium salts facilitated the integration of glycals with drugs, natural products, and peptides. This method allows the incorporation of diverse glycals into structurally varied aglycon components without directing groups or prefunctionalization and provides a practical method for synthesizing C-aryl glycosides, offering a new avenue for the production of complex glycosides with potential applications. |
| WOS关键词 | H FUNCTIONALIZATION ; GLYCOSYLATION |
| 资助项目 | National Natural Science Foundation of China[2022YFA1302900] ; National Key R&D Program of China[82130105] ; National Key R&D Program of China[22337003] ; National Key R&D Program of China[82121005] ; National Key R&D Program of China[82322063] ; National Key R&D Program of China[22177124] ; National Key R&D Program of China[LG-GG-202204-02] ; National Key R&D Program of China[LG-GG-202403-01] ; National Natural Science Foundation of China[23XD1460300] ; Program of Shanghai Academic Research Leader |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001187256900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310172]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Dechuan; Wang, Jiang; Liu, Hong |
| 作者单位 | 1.Lingang Lab, Shanghai 200031, Peoples R China 2.China Pharmaceut Univ, Nanjing 211198, Jiangsu, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xinxin,Zeng, Mingjie,Li, Yazhou,et al. Palladium(II)-Catalyzed Heck Coupling: Direct Stereoselective Synthesis of C-Aryl Glycosides from Nonactivated Glycals and Thianthrenium Salts[J]. ORGANIC LETTERS,2024:5. |
| APA | Wei, Xinxin,Zeng, Mingjie,Li, Yazhou,Wang, Dechuan,Wang, Jiang,&Liu, Hong.(2024).Palladium(II)-Catalyzed Heck Coupling: Direct Stereoselective Synthesis of C-Aryl Glycosides from Nonactivated Glycals and Thianthrenium Salts.ORGANIC LETTERS,5. |
| MLA | Wei, Xinxin,et al."Palladium(II)-Catalyzed Heck Coupling: Direct Stereoselective Synthesis of C-Aryl Glycosides from Nonactivated Glycals and Thianthrenium Salts".ORGANIC LETTERS (2024):5. |
入库方式： OAI收割
来源：上海药物研究所
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