Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Wang, Ge2,3; Ding, Ao-Xue2,3; Qin, Guo-Qin2,3; Chen, Tong1,3; Hu, Xiang-Gang2,3; Zheng, Liu2,3; Du, Gao-Xiang1,3; Wang, Wenqiong2,3; Xuan, Lijiang2,3
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2024-04-01 |
| 卷号 | 174页码:7 |
| 关键词 | Dimericent-kauranoids Anti-inflammatory activities ent-kauranoids |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2024.105840 |
| 通讯作者 | Wang, Wenqiong(wenqiong1019@simm.ac.cn) ; Xuan, Lijiang(ljxuan@simm.ac.cn) |
| 英文摘要 | The phytochemical investigation of the aerial parts of Isodon japonica var. glaucocalyx afforded four undescribed (glaucocalyxin O -R, 1-4) and six known ent-kauranoids (5-10). Their structures were established using NMR and MS measurements. Compounds 1 and 2 are dimeric ent-kaurane-type diterpenoids. Moreover, the plausible biogenetic pathways for compounds 1 and 2 were proposed as Michael addition between two monomers. Eight compounds were assayed for their anti-inflammatory activity by evaluating NO production in LPS-induced RAW 267.4 cells, and compounds 7, 8 and 9 exhibited relatively remarkable anti-inflammatory activities at 10 mu M. |
| WOS关键词 | DITERPENOIDS |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001177643300001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310184]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wenqiong; Xuan, Lijiang |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ge,Ding, Ao-Xue,Qin, Guo-Qin,et al. Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities[J]. FITOTERAPIA,2024,174:7. |
| APA | Wang, Ge.,Ding, Ao-Xue.,Qin, Guo-Qin.,Chen, Tong.,Hu, Xiang-Gang.,...&Xuan, Lijiang.(2024).Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities.FITOTERAPIA,174,7. |
| MLA | Wang, Ge,et al."Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities".FITOTERAPIA 174(2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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