Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity
文献类型：期刊论文
| 作者 | Wu, Pei-Qian3; Liu, Zhen-Di1; Ren, Yu-Hao3; Zhou, Jun-Su3; Liu, Qun-Fang3 ; Wu, Yan3; Zhang, Ji-Li1; Zhou, Bin2,3; Yue, Jian-Min2,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2024-04-01 |
| 卷号 | 220页码:11 |
| ISSN号 | 0031-9422 |
| 关键词 | Alstonia scholaris Apocynaceae Monoterpenoid indole alkaloids Anti toxoplasma activity |
| DOI | 10.1016/j.phytochem.2024.113993 |
| 通讯作者 | Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Nine previously unreported various types of monoterpenoid indole alkaloids, together with seven known analogues were isolated from the stem barks of Alstonia scholaris through a silica gel free methodology. The structures of 1-9 were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compound 1 is a modified echitamine-type alkaloid with a novel 6/5/5/7/6/6 hetero hexacyclic bridged ring system, and 8 and 9 exist as a zwitterion and trifluoroacetate salt, respectively. The anti-Toxoplasma activity of all isolates on infected Vero cells were evaluated, which revealed that compound 14 at 0.24 mu M displayed potent activity. This study expanded the structural diversity of alkaloids of A. scholaris, and presented their potential application in anti-Toxoplasma drug development. |
| WOS关键词 | LEAVES ; STRYCHNAN |
| 资助项目 | Shanghai Municipal Science and Technology Major Project ; Youth Innovation Promotion Association of CAS[2022283] ; National Natural Science Foundation of China[22007095] ; National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[82102426] ; Natural Science Foundation of Zhejiang Province[LQ22H190001] ; Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University[SMECD2023004] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:001174434300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310199]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Ningbo Univ, Hlth Sci Ctr, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Pei-Qian,Liu, Zhen-Di,Ren, Yu-Hao,et al. Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity[J]. PHYTOCHEMISTRY,2024,220:11. |
| APA | Wu, Pei-Qian.,Liu, Zhen-Di.,Ren, Yu-Hao.,Zhou, Jun-Su.,Liu, Qun-Fang.,...&Yue, Jian-Min.(2024).Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity.PHYTOCHEMISTRY,220,11. |
| MLA | Wu, Pei-Qian,et al."Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity".PHYTOCHEMISTRY 220(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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