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Heparin-Conjugated ACE2-Bearing Extracellular Vesicles As Engineered Dual-Decoy for Combating the SARS-CoV-2 Omicron Variant via Pulmonary Delivery

文献类型：期刊论文

作者Tu, Bin8,9,10; Pan, Zhenzhen6,7; Wang, Huiyuan10; Qu, Jingkun5,10; Sun, Feifei4,10; Shi, Mingjie10; Zhang, Yingyan3; Wu, Han9,10; Muhitdinov, Bahtiyor2; Huang, Yongzhuo1,8,9,10
刊名ACS MATERIALS LETTERS
出版日期2024-03-05
页码9
DOI10.1021/acsmaterialslett.3c01442
通讯作者Wang, Huiyuan(wanghuiyuan@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要The very highly contagious Omicron variant of SARS-CoV-2, repeated infection, and long COVID symptoms continue to be a health threat with few convenient preventive or therapeutic methods suitable for common use. Spike-glycan interactions play an essential role in SARS-CoV-2 infections, and heparan sulfate acts as a coreceptor for mediating the cell entry of the virus. In response to this challenge, we proposed a dual-decoy strategy using both heparin (an analogue of heparan sulfate) and ACE2 to neutralize SARS-CoV-2. We developed a heparin-conjugated ACE2-bearing extracellular vesicle system (haEVs), serving as nano dual bait, with high efficiency in neutralizing the Omicron variant through interactions with the viral Spike protein. In vitro experiments showed that haEVs bound to the pseudovirus of SARS-CoV-2 and effectively prevented the pseudovirus infection of host cells. In vivo experiments further demonstrated that inhalable haEVs effectively blocked the pseudovirus infection of lung tissue of the Omicron variant with good biosafety. This dual-decoy approach presents a promising avenue for combating SARS-CoV-2, especially the Omicron variant, with the advantage of self-administration for preventive and therapeutic applications.
资助项目National Key Research and Development Program of China[2021YFE0103100] ; National Key Research and Development Program of China[2022YFE0203600] ; National Nature Science Foundation of China[81925035] ; National Nature Science Foundation of China[82341232] ; Sanofi-SIBS Yong Faculty Award (China) ; Youth Innovation Promotion Association (China) ; Department of Science and Technology of Guangdong Province (High-Level New RD Institute)[2019B090904008] ; Department of Science and Technology of Guangdong Province(High-Level Innovative Research Institute )[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:001180338200001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/310202]  
专题新药研究国家重点实验室
通讯作者Wang, Huiyuan; Huang, Yongzhuo
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Anim Ctr, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310024, Zhejiang, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
6.Guangxi Univ Chinese Med, Expt Teaching Ctr, Nanning 530200, Peoples R China
7.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510405, Peoples R China
8.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
10.Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Tu, Bin,Pan, Zhenzhen,Wang, Huiyuan,et al. Heparin-Conjugated ACE2-Bearing Extracellular Vesicles As Engineered Dual-Decoy for Combating the SARS-CoV-2 Omicron Variant via Pulmonary Delivery[J]. ACS MATERIALS LETTERS,2024:9.
APA Tu, Bin.,Pan, Zhenzhen.,Wang, Huiyuan.,Qu, Jingkun.,Sun, Feifei.,...&Huang, Yongzhuo.(2024).Heparin-Conjugated ACE2-Bearing Extracellular Vesicles As Engineered Dual-Decoy for Combating the SARS-CoV-2 Omicron Variant via Pulmonary Delivery.ACS MATERIALS LETTERS,9.
MLA Tu, Bin,et al."Heparin-Conjugated ACE2-Bearing Extracellular Vesicles As Engineered Dual-Decoy for Combating the SARS-CoV-2 Omicron Variant via Pulmonary Delivery".ACS MATERIALS LETTERS (2024):9.

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来源：上海药物研究所

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