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Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer

文献类型：期刊论文

作者Gong, Xiang6,7,8; Zheng, Chao6,7,8; Cai, Ying1,6,7; Zhang, Wen6,7,8; Zhu, Binyu1,6,7; Rong, Rong3; Kong, Ying3; Zhang, Yuan2; Wang, Jian8; Li, Yaping1,3,6,7
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2024-03-01
卷号367页码:637-648
关键词Peptide-drug conjugate Synthetic high-density lipoprotein Adenosine Immunogenic cell death Immunosuppression
ISSN号0168-3659
DOI10.1016/j.jconrel.2024.01.064
通讯作者Wang, Jian(wangjian11@sinopharm.com) ; Li, Yaping(ypli@simm.ac.cn) ; Zhang, Pengcheng(zhangpch1@shanghaitech.edu.cn)
英文摘要Adenosine (ADO) is a common chemotherapy-associated immune checkpoint that hinders anti-tumor immunitymediated efficacy of chemotherapy. Herein, we created a synthetic high-density lipoprotein (sHDL) by coassembly of a doxorubicin (DOX)-apolipoprotein A1 mimetic peptide conjugate, PSB-603 (an A2BR inhibitor), phospholipid, and cholesterol oleate with a microfluidic-based method. The obtained DP-sHDL showed a selfpromoted drug delivery to cancer cells via remodeling tumor microenvironment. DP-sHDL could trigger the release of ATP from cancer cells and inhibit its conversion into ADO. Consequently, DP-sHDL, while increasing immunogenic cell death, reduced intratumoral ADO levels by 58%. This treatment improved both the density and activity of CD8+ T cells as well as NK cells and relieved the immunosuppressive microenvironment, and led to a substantial inhibition of 4T1 tumor growth, thereby extending the survival of mice. The efficacy of DP-sHDL could be further improved when used in combination with immune checkpoint blockade therapy. We envision that this platform provides a simple yet promising strategy to enhance anti-tumor response of chemotherapy by relieving treatment-associated immunosuppression.
WOS关键词IMMUNOGENIC CELL-DEATH ; RECEPTOR ; CHEMOTHERAPY ; CHOLESTEROL ; INHIBITION ; SUPPRESSES ; EXPRESSION ; RESISTANCE ; BLOCKADE ; THERAPY
资助项目National Key Research and Development Program of China[2022YFC3401400] ; National Natural Science Foundation of China[32171374] ; National Natural Science Foundation of China[82270064] ; National Natural Science Foundation of China[32371457] ; Shandong Provincial Natural Science Foundation[ZR2019ZD25]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001183732600001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/310351]  
专题新药研究国家重点实验室
通讯作者Wang, Jian; Li, Yaping; Zhang, Pengcheng
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Tongji Univ, Shanghai Pulm Hosp, Dept Pulm & Crit Care Med, Sch Med, Shanghai 200433, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
4.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China
5.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
7.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.China State Inst Pharmaceut Ind, Natl Adv Med Engn Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Gong, Xiang,Zheng, Chao,Cai, Ying,et al. Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer[J]. JOURNAL OF CONTROLLED RELEASE,2024,367:637-648.
APA Gong, Xiang.,Zheng, Chao.,Cai, Ying.,Zhang, Wen.,Zhu, Binyu.,...&Zhang, Pengcheng.(2024).Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer.JOURNAL OF CONTROLLED RELEASE,367,637-648.
MLA Gong, Xiang,et al."Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer".JOURNAL OF CONTROLLED RELEASE 367(2024):637-648.

入库方式： OAI收割

来源：上海药物研究所

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