A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria
文献类型：期刊论文
| 作者 | Guan, Dongliang2,3,4; Liu, Jiaxiang4; Chen, Feifei1,3,4; Li, Jian1,3,4; Wang, Xiaowen2; Lu, Weiwei4; Suo, Yanrui4; Tang, Feng3,4; Lan, Lefu1,3; Lu, Xiaojie3,4
|
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2024-03-05 |
| 卷号 | 67期号:5页码:3778-3794 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.3c02197 |
| 通讯作者 | Guan, Dongliang(guandongliang@simm.ac.cn) ; Lan, Lefu(llan@ucas.ac.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn) ; Huang, Wei(huangwei@simm.ac.cn) |
| 英文摘要 | It is an urgent need to tackle the global crisis of multidrug-resistant bacterial infections. We report here an innovative strategy for large-scale screening of new antibacterial agents using a whole bacteria-based DNA-encoded library (DEL) of vancomycin derivatives via peripheral modifications. A bacterial binding affinity assay was established to select the modification fragments in high-affinity compounds. The optimal resynthesized derivatives demonstrated excellently enhanced activity against various resistant bacterial strains and provided useful structures for vancomycin derivatization. This work presents the new concept in a natural product-templated DEL and in antibiotic discovery through bacterial affinity screening, which promotes the fight against drug-resistant bacteria. |
| 资助项目 | National Natural Science Foundation of China |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001183213300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310369]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guan, Dongliang; Lan, Lefu; Lu, Xiaojie; Huang, Wei |
| 作者单位 | 1.Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Biotherapeut Discovery Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Dongliang,Liu, Jiaxiang,Chen, Feifei,et al. A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria[J]. JOURNAL OF MEDICINAL CHEMISTRY,2024,67(5):3778-3794. |
| APA | Guan, Dongliang.,Liu, Jiaxiang.,Chen, Feifei.,Li, Jian.,Wang, Xiaowen.,...&Huang, Wei.(2024).A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria.JOURNAL OF MEDICINAL CHEMISTRY,67(5),3778-3794. |
| MLA | Guan, Dongliang,et al."A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria".JOURNAL OF MEDICINAL CHEMISTRY 67.5(2024):3778-3794. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。