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Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins

文献类型：期刊论文

作者Yu, Qian4,5; Wang, Zheng4,5; Tu, Yutong3; Cao, Yu2; Zhu, Huajian4,5; Shao, Jiaan4,5; Zhuang, Rangxiao1,2; Zhou, Yubo1,3; Zhang, Jiankang1,4,5
刊名BIOORGANIC CHEMISTRY
出版日期2024-04-01
卷号145页码:17
关键词20S proteasome Proteasome activation IDPs Undruggable Protein homeostasis
ISSN号0045-2068
DOI10.1016/j.bioorg.2024.107217
通讯作者Zhuang, Rangxiao(zhuangrangxiao@sina.com) ; Zhou, Yubo(ybzhou@simm.ac.cn) ; Zhang, Jiankang(zhang_jk@zucc.edu.cn)
英文摘要Intrinsically disordered proteins (IDPs) are characterized by their inability to adopt well-defined tertiary structures under physiological conditions. Nonetheless, they often play pivotal roles in the progression of various diseases, including cancer, neurodegenerative disorders, and cardiovascular ailments. Owing to their inherent dynamism, conventional drug design approaches based on structural considerations encounter substantial challenges when applied to IDPs. Consequently, the pursuit of therapeutic interventions directed towards IDPs presents a complex endeavor. While there are indeed existing methodologies for targeting IDPs, they are encumbered by noteworthy constrains. Hence, there exists an imminent imperative to investigate more efficacious and universally applicable strategies for modulating IDPs. Here, we present an overview of the latest advancements in the research pertaining to IDPs, along with the indirect regulation approach involving the modulation of IDP degradation through proteasome. By comprehending these advancements in research, novel insights can be generated to facilitate the development of new drugs targeted at addressing the accumulation of IDPs in diverse pathological conditions.
WOS关键词20S PROTEASOME ; STRUCTURAL DISORDER ; UNSTRUCTURED PROTEINS ; 26S PROTEASOME ; TRANSCRIPTION ; DEGRADATION ; MECHANISMS ; INHIBITOR ; RECOGNITION ; DOMAINS
资助项目Zhejiang Provincial Natural Science Foundation of China[LY24H300003]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001188397500001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/310397]  
专题中国科学院上海药物研究所
通讯作者Zhuang, Rangxiao; Zhou, Yubo; Zhang, Jiankang
作者单位1.Hangzhou City Univ, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
2.Hangzhou Xixi Hosp, Dept Pharmaceut Preparat, Hangzhou 310023, Zhejiang, Peoples R China
3.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
5.Hangzhou City Univ, Sch Med, Key Lab Novel Targets & Drug Study Neural Repair Z, Hangzhou 310015, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Qian,Wang, Zheng,Tu, Yutong,et al. Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins[J]. BIOORGANIC CHEMISTRY,2024,145:17.
APA Yu, Qian.,Wang, Zheng.,Tu, Yutong.,Cao, Yu.,Zhu, Huajian.,...&Zhang, Jiankang.(2024).Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins.BIOORGANIC CHEMISTRY,145,17.
MLA Yu, Qian,et al."Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins".BIOORGANIC CHEMISTRY 145(2024):17.

入库方式： OAI收割

来源：上海药物研究所

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