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Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis

文献类型：期刊论文

作者Zhao, Jin-Xin1,2; Ge, Zhan-Peng2; Yue, Jian-Min1,2
刊名NATURAL PRODUCT REPORTS
出版日期2024-03-14
页码28
ISSN号0265-0568
DOI10.1039/d3np00067b
通讯作者Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Covering: up to the end of 2023Cephalotane diterpenoids are a unique class of natural products exclusive to the genus Cephalotaxus, featuring a rigid 7,6,5,6-fused tetracyclic architecture. The study of cephalotanes dates back to the 1970s, when harringtonolide (1), a Cephalotaxus troponoid with a peculiar norditerpenoid carbon skeleton, was first discovered. In recent years, prototype C20 diterpenoids proposed as cephalotane were disclosed, which triggered intense studies on this diterpenoid family. To date, a cumulative total of 105 cephalotane diterpenoids with great structural diversity and biological importance have been isolated. In addition, significant advances have been made in the field of total synthesis and biosynthesis of cephalotanes in recent years. This review provides a complete overview of the chemical structures, bioactivities, biosynthetic aspects, and completed total synthesis of all the isolated cephalotane diterpenoids, which will help guide future research on this class of compounds. This review summarizes a total of 105 cephalotane diterpenoids, covering their isolation, structural features, biological activities, biosynthetic proposals, and completed total synthesis.
WOS关键词IODOSOBENZENE DIACETATE ; NATURAL-PRODUCTS ; HAINANOLIDE ; NORDITERPENOIDS ; EFFICIENT ; TROPONE ; HARRINGTONOLIDE ; STEREOCHEMISTRY ; CONSTRUCTION ; CEPHANOLIDES
资助项目National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; National Natural Science Foundation of China[22PJ1415800] ; Shanghai Pujiang Program[2022282] ; Shanghai Pujiang Program[2023293] ; Youth Innovation Promotion Association of Chinese Academy of Sciences
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:001184722000001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/310409]  
专题新药研究国家重点实验室
通讯作者Yue, Jian-Min
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Jin-Xin,Ge, Zhan-Peng,Yue, Jian-Min. Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis[J]. NATURAL PRODUCT REPORTS,2024:28.
APA Zhao, Jin-Xin,Ge, Zhan-Peng,&Yue, Jian-Min.(2024).Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis.NATURAL PRODUCT REPORTS,28.
MLA Zhao, Jin-Xin,et al."Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis".NATURAL PRODUCT REPORTS (2024):28.

入库方式： OAI收割

来源：上海药物研究所

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