Non-electrophysiological techniques targeting transient receptor potential (TRP) gene of gastrointestinal tract
文献类型：期刊论文
| 作者 | Jiang, Yuting3,4; Shen, Lan2,4; Wang, Bing1,3,4 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-03-01 |
| 卷号 | 262页码:17 |
| 关键词 | Non-electrophysiological techniques Transient receptor potential channels Gastrointestinal tract Drug discovery |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.129551 |
| 通讯作者 | Shen, Lan(alansusu@sina.com) ; Wang, Bing(bwang@simm.ac.cn) |
| 英文摘要 | Transient receptor potential (TRP) channels are cation channels related to a wide range of physical and chemical stimuli, they are expressed all along the gastrointestinal system, and a myriad of diseases are often associated with aberrant expression or mutation of the TRP gene, suggesting that TRPs are promising targets for drug therapy. Therefore, a better understanding of the information of TRPs in health and disease could facilitate the development of effective drugs for the treatment of gastrointestinal diseases like IBD. But there are very few generalizations about the experimental techniques studied in this field. In view of the promise of TRP as a therapeutic target, we discuss experimental methods that can be used for TRPs including their distribution, function and interaction with other proteins, as well as some promising emerging technologies to provide experimental methods for future studies. |
| WOS关键词 | IMAGING MASS-SPECTROMETRY ; PARAFFIN-EMBEDDED TISSUE ; ION-CHANNEL ; SUBSTANCE-P ; VANILLOID 1 ; EXPERIMENTAL COLITIS ; VISCERAL HYPERSENSITIVITY ; COLONIC INFLAMMATION ; ULCERATIVE-COLITIS ; FUNCTIONAL-ROLE |
| 资助项目 | Program of Shanghai Committee of Science and Technology, China[21ZR1475200] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001187957400001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310523]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shen, Lan; Wang, Bing |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Hai ke Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cai lun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Yuting,Shen, Lan,Wang, Bing. Non-electrophysiological techniques targeting transient receptor potential (TRP) gene of gastrointestinal tract[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,262:17. |
| APA | Jiang, Yuting,Shen, Lan,&Wang, Bing.(2024).Non-electrophysiological techniques targeting transient receptor potential (TRP) gene of gastrointestinal tract.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,262,17. |
| MLA | Jiang, Yuting,et al."Non-electrophysiological techniques targeting transient receptor potential (TRP) gene of gastrointestinal tract".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 262(2024):17. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。