Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma
文献类型：期刊论文
| 作者 | Lai, Yue2; Guo, Shushan2; Tang, Qiongwei2; Chang, Gaomei2; Zhang, Hui2; Li, Bo1; Feng, Qilin2; Hu, Ke2; Xu, Zhijian1 ; Gao, Xuejie2
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| 刊名 | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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| 出版日期 | 2024-04-01 |
| 卷号 | 754页码:11 |
| 关键词 | Dihydrocelastrol Angiogenesis Apoptosis Jun B p65 |
| ISSN号 | 0003-9861 |
| DOI | 10.1016/j.abb.2024.109929 |
| 通讯作者 | Zhu, Weiliang(wlzhu@simm.ac.cn) ; Shi, Jumei(shijumei@tongji.edu.cn) |
| 英文摘要 | Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Although treatment options have improved, a large proportion of patients show low survival rates, highlighting an urgent need for novel therapeutic strategies. The aim of this study was to investigate the efficacy of the new small-molecule compound dihydrocelastrol (DHCE), acquired through the structural modification of celastrol (CE), in the treatment of DLBCL. DHCE showed potent anti-lymphoma efficacy and synergistic effects with doxorubicin. DHCE triggered DLBCL cell apoptosis and G0/G1-phase blockade, thereby hindering angiogenesis. DHCE inhibited B-cell receptor cascade signalling and Jun B and p65 nuclear translocation, thereby suppressing protumourigenic signalling. Finally, DHCE exerted lower toxicity than CE, which showed severe hepatic, renal, and reproductive toxicity in vivo. Our findings support further investigation of the clinical efficacy of DHCE against DLBCL. |
| WOS关键词 | NF-KAPPA-B ; RECEPTOR ; CELASTROL ; CANCER ; INFLAMMATION ; ACTIVATION ; PATHWAYS ; TARGETS ; AP-1 |
| 资助项目 | National Natural Science Founda-tion of China[82170190] ; National Natural Science Founda-tion of China[82070224] ; National Natural Science Founda-tion of China[82200228] ; National Natural Science Founda-tion of China[82170200] ; National Natural Science Founda-tion of China[82170201] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:001197860300001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310526]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, Weiliang; Shi, Jumei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Tongji Univ, Shanghai East Hosp, Dept Hematol, Sch Med, Shanghai 200120, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Yue,Guo, Shushan,Tang, Qiongwei,et al. Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,2024,754:11. |
| APA | Lai, Yue.,Guo, Shushan.,Tang, Qiongwei.,Chang, Gaomei.,Zhang, Hui.,...&Shi, Jumei.(2024).Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,754,11. |
| MLA | Lai, Yue,et al."Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma".ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 754(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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