Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis
文献类型：期刊论文
| 作者 | Ge, Zhan-Peng2; Xu, Jin-Biao2; Zhao, Peng2; Xiang, Mai2; Zhou, Yu2 ; Lin, Ze-Min2; Zuo, Jian-Ping2; Zhao, Jin-Xin1,2; Yue, Jian-Min1,2
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2024-05-01 |
| 卷号 | 221页码:9 |
| ISSN号 | 0031-9422 |
| 关键词 | Cephalotaxus fortunei var. alpina Cephalotaxus sinensis Cephalotaxaceae Diterpenoids Cephalotane CeforloidsA-F Immunosuppressive activity |
| DOI | 10.1016/j.phytochem.2024.114038 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Cephalotanes are a rare class of diterpenoids occurring exclusively in Cephalotaxus plants. The intriguing structures and promising biological activities for this unique compound class prompt us to investigate C. fortunei var. alpina and C. sinensis, leading to the isolation of six undescribed cephalotane-type diterpenoids and/or norditerpenoids, ceforloids A-F (1-6). Their structures were elucidated by comprehensive analysis of spectroscopic data, including ECD and single -crystal X-ray diffraction studies, as well as quantum chemical calculations. Compound 1 possesses an unprecedented norditerpenoid skeleton featuring an unusual acetophenone moiety, and originated putatively from a disparate biogenetic pathway. Compounds 4 and 5 incorporate a unique 12,13p-hydroxybenzylidene acetal motif. Compound 6 is a rare cephalotane-type diterpenoid glycoside. Immunosuppressive assays showed that compounds 2 and 6 exhibited mild suppressive activity against the activated T and B lymphocytes proliferation. These findings not only expanded the structural diversity of this small group of diterpenoids, but also explored their potential as novel structures for the development of immunosuppressive agents. |
| WOS关键词 | NATURAL-PRODUCTS ; NORDITERPENOIDS ; HAINANOLIDOL |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; National Natural Science Foundation of China[82374108] ; Youth Innovation Promotion Association of CAS[2022282] ; Youth Innovation Promotion Association of CAS[2023293] ; Biological Resources Program of CAS[KFJ-BRP-008] ; Shanghai Institute of Materia Medica of CAS[SIMM0120232003] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:001194177700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310538]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Zhan-Peng,Xu, Jin-Biao,Zhao, Peng,et al. Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis[J]. PHYTOCHEMISTRY,2024,221:9. |
| APA | Ge, Zhan-Peng.,Xu, Jin-Biao.,Zhao, Peng.,Xiang, Mai.,Zhou, Yu.,...&Yue, Jian-Min.(2024).Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis.PHYTOCHEMISTRY,221,9. |
| MLA | Ge, Zhan-Peng,et al."Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis".PHYTOCHEMISTRY 221(2024):9. |
入库方式： OAI收割
来源：上海药物研究所
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