Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
文献类型：期刊论文
| 作者 | Balavaishnavi, B.6; Kamaraj, M.4,5; Nithya, T. G.3; Santhosh, P.2; Gokilalakshmi, S.6; Shaik, Mohammed Rafi1 |
| 刊名 | MEDICAL ONCOLOGY
 |
| 出版日期 | 2024-03-29 |
| 卷号 | 41期号:5页码:14 |
| 关键词 | Anti-proliferative effect Hippo pathway MDA-MB-231 cells Apoptosis Rauvolfia tetraphylla |
| ISSN号 | 1357-0560 |
| DOI | 10.1007/s12032-024-02341-5 |
| 通讯作者 | Nithya, T. G.(nithyag@srmist.edu.in) |
| 英文摘要 | Rauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional medicine for various disease treatments. However, the tumor suppressor activity of R. tetraphylla and its phytocompounds were not explored against triple-negative breast cancer. The current research investigated the impact of R. tetraphylla methanolic extract (RTE) and its isolated compounds Ajmaline (RTC1) and Reserpine (RTC2) on triple-negative breast cancer cell line (MDA-MB-231) focusing on anti-proliferative effects. Our study imparts that RTE and RTC2 showed promising cytotoxic effects compared to RTC1. So further experiments have proceeded with RTE and RTC2, to evaluate its proliferation, migration, and apoptotic effect. The result shows around 80% of cells were observed in the G0/G1 phase in cell cycle analysis indicating the cell cycle inhibition and duel staining clearly showed the apoptotic effect. The migration of cells after the scratch was 60.45% observed in control and 90% in treated cells showing the inhibition of migration. ROS distribution was intense compared to control indicating the increased ROS stress in treated cells. Both RTE and RTC2-treated cells showed the potential to suppress proliferation and induce apoptotic change by upregulating BAX and MST-1 and suppressing Bcl2, LATS-1, and YAP, proving that deregulation of YAP resulting in the blockage of TEAD-YAP complex and inhibit proliferation. Therefore, R. tetraphylla extract and its isolated compounds were demonstrated to find its ability to act against MDA-MB-231 and these findings will help adjudicate it as a therapeutic drug against experimental triple-negative breast cancer. |
| WOS关键词 | PATHWAY ; YAP ; GROWTH ; EXTRACTS ; PLANTS ; GENE |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:001195269700001 |
| 出版者 | HUMANA PRESS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310541]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Nithya, T. G. |
| 作者单位 | 1.King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.SRM Inst Sci & Technol, Fac Sci & Humanities, Dept Biochem, Kattankulathur 603203, Tamil Nadu, India 4.INTI Int Univ, Fac Hlth & Life Sci, Life Sci Div, Nilai 71800, Malaysia 5.SRM Inst Sci & Technol Ramapuram, Fac Sci & Humanities, Dept Biotechnol, Chennai 600089, Tamil Nadu, India 6.SRM Inst Sci & Technol, Fac Sci & Humanities, Dept Biotechnol, Kattankulathur 603203, Tamil Nadu, India |
| 推荐引用方式 GB/T 7714 | Balavaishnavi, B.,Kamaraj, M.,Nithya, T. G.,et al. Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer[J]. MEDICAL ONCOLOGY,2024,41(5):14. |
| APA | Balavaishnavi, B.,Kamaraj, M.,Nithya, T. G.,Santhosh, P.,Gokilalakshmi, S.,&Shaik, Mohammed Rafi.(2024).Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer.MEDICAL ONCOLOGY,41(5),14. |
| MLA | Balavaishnavi, B.,et al."Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer".MEDICAL ONCOLOGY 41.5(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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