Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products
文献类型：期刊论文
| 作者 | Hu, Yun-shu2,3; Zhang, Jian-qing2; Wei, Wen-long2; Yang, Huan-ya3; Sha, Fei2; Shen, Xuan-jing2; Yao, Shuai2; Li, Jia-yuan2; Qu, Hua2; Li, Ping1 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2024-03-21 |
| 卷号 | 72期号:13页码:7438-7456 |
| ISSN号 | 0021-8561 |
| 关键词 | aristolochic acid analogues(AAAs) Asari Radix et Rhizoma identification quantification toxicity |
| DOI | 10.1021/acs.jafc.4c00751 |
| 通讯作者 | Guo, Dean(daguo@simm.ac.cn) |
| 英文摘要 | Aristolochic acid analogues (AAAs) are well-known toxins. We performed the first comprehensive screening on AAAs in Asari Radix et Rhizoma (underground part of Asarum heterotropoides Schmidt), the only Aristolochiaceae plant widely used in clinical practice. LC-HRMS revealed 70 trace AAAs using polygonal mass defect filtering and precursor ion list strategies, 38 of which were newly discovered in A. heterotropoides. UHPLC-QTrap-MS/MS was then utilized for quantitative/semiquantitative analysis of 26 abundant compounds. Seventeen AAAs were detected from 91 batches of A. heterotropoides and 20 AAAs from 166 consumable products. For 141 Asari-containing proprietary products, aristolactam I and aristolactam II-glucoside exhibited the widest distribution, present in 98% products. AA IVa was the most abundant, detected in 91%. Notably, 60% of the products contained AA I (0.03-0.79 ppm). The safety was assessed using linear extrapolation, permitted daily exposure, cumulative amount, and the margin of exposure. It is recommended that AA I content be limited to 3 ppm. |
| WOS关键词 | RENAL TISSUE ; NEPHROPATHY ; TOXICITY ; EXPOSURE ; INJURY |
| 资助项目 | National Natural Science Foundation of China[32141005] ; National Natural Science Foundation of China[21YF1455800] ; Shanghai Sailing Program[GUIKEAA22096029] ; Guangxi Science and Technology Major Project[2021ZD0017] ; Science and Technology Major Project of Inner Mongolia |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001189960700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310559]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Dean |
| 作者单位 | 1.Natl Clin Res Ctr Kidney Dis, Natl Key Lab Kidney Dis, Beijing Key Lab Kidney Dis Res, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Yun-shu,Zhang, Jian-qing,Wei, Wen-long,et al. Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024,72(13):7438-7456. |
| APA | Hu, Yun-shu.,Zhang, Jian-qing.,Wei, Wen-long.,Yang, Huan-ya.,Sha, Fei.,...&Guo, Dean.(2024).Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,72(13),7438-7456. |
| MLA | Hu, Yun-shu,et al."Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72.13(2024):7438-7456. |
入库方式： OAI收割
来源：上海药物研究所
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