Verteporfin reverses progestin resistance through YAP
文献类型：期刊论文
| 作者 | Lina Wei1; Xiaohong Ma1; Yixin Hou1; Tianyi Zhao1; Rui Sun1; Chunping Qiu1; Yao Liu1; Ziyi Qiu1; Zhiming Liu1; Jie Jiang1 |
| 刊名 | CELL DEATH DISCOVERY
 |
| 出版日期 | 2023 |
| 卷号 | 9期号:1 |
| ISSN号 | 2058-7716 |
| 英文摘要 | Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP and TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway, promote viability, metastasis and also drug resistance of malignant tumors. According to our microarray analysis, YAP/TAZ were upregulated in progestin resistant IshikawaPR cell versus progestin sensitive Ishikawa cell, which implied that YAP/TAZ may be a vital promotor of resistance to progestin. We found YAP/TAZ had higher expression levels among the resistant tissues than sensitive tissues. In addition, knocking down YAP/TAZ decreased cell viability, inhibited cell migration and invasion and increased the sensitivity of IshikawaPR cell to progestin. On the contrary, overexpression of YAP/TAZ increased cell proliferation, metastasis and promoted progestin resistance. We also confirmed YAP/TAZ were involved in progestin resistant process by regulating PI3K-Akt pathway. Furthermore, Verteporfin as an inhibitor of YAP/TAZ could increase sensitivity of IshikawaPR cells to progestin in vivo and in vitro. Our study for the first time indicated that YAP/TAZ play an important role in progestin resistance by regulating PI3K-Akt pathway in EC, which may provide ideas for clinical targeted therapy of progestin resistance. |
| 语种 | 英语 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/34540]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 作者单位 | 1.山东大学 2.中国科学院烟台海岸带研究所 |
| 推荐引用方式 GB/T 7714 | Lina Wei,Xiaohong Ma,Yixin Hou,et al. Verteporfin reverses progestin resistance through YAP[J]. CELL DEATH DISCOVERY,2023,9(1). |
| APA | Lina Wei.,Xiaohong Ma.,Yixin Hou.,Tianyi Zhao.,Rui Sun.,...&Jie Jiang.(2023).Verteporfin reverses progestin resistance through YAP.CELL DEATH DISCOVERY,9(1). |
| MLA | Lina Wei,et al."Verteporfin reverses progestin resistance through YAP".CELL DEATH DISCOVERY 9.1(2023). |
入库方式： OAI收割
来源：烟台海岸带研究所
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