Glioblastoma upregulates SUMOylation of hnRNP A2
文献类型：期刊论文
| 作者 | Qindong Guo1; Yang Fan1; Qingtong Wang1; Boyan Li1; Wei Qiu1; Yanhua Qi1; Ziwen Pan1; Shouji Zhang1; Shulin Zhao1; Kehui Yang1 |
| 刊名 | CELL DEATH & DISEASE
 |
| 卷号 | 14期号:2 |
| ISSN号 | 2041-4889 |
| 英文摘要 | Glioma is the most common malignant tumor of the central nervous system in adults. The tumor microenvironment (TME) is related to poor prognosis in glioma patients. Glioma cells could sort miRNA into exosomes to modify TME. And hypoxia played an important role in this sorting process, but the mechanism is not clear yet. Our study was to find miRNAs sorted into glioma exosomes and reveal the sorting process. Sequencing analysis of glioma patients cerebrospinal fluid (CSF) and tissue showed that miR-204-3p tends to be sorted into exosomes. miR-204-3p suppressed glioma proliferation through the CACNA1C/MAPK pathway. hnRNP A2/B1 can accelerate exosome sorting of miR-204-3p by binding a specific sequence. Hypoxia plays an important role in exosome sorting of miR-204-3p. Hypoxia can upregulate miR-204-3p by upregulating the translation factor SOX9. Hypoxia promotes the transfer of hnRNP A2/B1 to the cytoplasm by upregulating SUMOylation of hnRNP A2/B1 to eliminate miR-204-3p. Exosomal miR-204-3p promoted tube formation of vascular endothelial cells through the ATXN1/STAT3 pathway. The SUMOylation inhibitor TAK-981 can inhibit the exosome-sorting process of miR-204-3p to inhibit tumor growth and angiogenesis. This study revealed that glioma cells can eliminate the suppressor miR-204-3p to accelerate angiogenesis under hypoxia by upregulating SUMOylation. The SUMOylation inhibitor TAK-981 could be a potential drug for glioma. This study revealed that glioma cells can eliminate the suppressor miR-204-3p to accelerate angiogenesis under hypoxia by upregulating SUMOylation. The SUMOylation inhibitor TAK-981 could be a potential drug for glioma. |
| 语种 | 英语 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/34550]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 作者单位 | 1.山东大学 2.Shandong Key Laboratory of Brain Function Remodeling 3.中国科学院烟台海岸带研究所 4.青岛大学 |
| 推荐引用方式 GB/T 7714 | Qindong Guo,Yang Fan,Qingtong Wang,et al. Glioblastoma upregulates SUMOylation of hnRNP A2[J]. CELL DEATH & DISEASE,14(2). |
| APA | Qindong Guo.,Yang Fan.,Qingtong Wang.,Boyan Li.,Wei Qiu.,...&Gang Li. |
| MLA | Qindong Guo,et al."Glioblastoma upregulates SUMOylation of hnRNP A2".CELL DEATH & DISEASE 14.2 |
入库方式： OAI收割
来源：烟台海岸带研究所
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