Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice
文献类型：期刊论文
| 作者 | Yuan, Jingyi1,2; Qin, Song1,3 ; Li, Wenjun1,3; Zhang, Yubing1,2; Wang, Yuting1; Chang, Xiulian2; Li, Lili1,3
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| 刊名 | JOURNAL OF MARINE SCIENCE AND ENGINEERING
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| 出版日期 | 2021-05-01 |
| 卷号 | 9期号:5页码:13 |
| 关键词 | fucoidan microbiome metabolomics gut microbiota |
| DOI | 10.3390/jmse9050505 |
| 通讯作者 | Li, Lili(llli@yic.ac.cn) |
| 英文摘要 | Fucoidan is a kind of polysaccharide with antitumor and antioxidant properties, which is mainly isolated from brown algae. Although there are many reports about the prebiotic effects of polysaccharides on hosts, there are few reports about the effects of fucoidan on blood biochemical indexes, intestinal microbiome, and metabolic function on healthy hosts. We applied 16S rRNA gene amplicon sequencing and LC-MS/MS metabolomics to evaluate the changes in the gut microbiome and metabolite profiles of fucoidan treatment in mice over 10 weeks. Fucoidan treatment modulated lipid metabolism, including significantly decreasing serum triglyceride level in healthy mice. Fucoidan also significantly inhibited serum lipopolysaccharide-binding protein (LBP) concentration, a biomarker of endotoxemia. Correlation analysis further showed that Lactobacillus animalis populations that were enriched by fucoidan demonstrated significantly negative correlations with serum triglyceride level. The abundance of Lactobacillus gasseri and Lactobacillus reuteri, increased by fucoidan supplementation, demonstrated significantly negative correlation with lipopolysaccharide-binding protein levels. Lactobacillus gasseri also demonstrated significantly positive correlations with three tryptophan-related metabolites, including indoleacrylic acid, 3-indoleacrylic acid, and 5-hydroxytryptamine, which were all increased by fucoidan administration. Combined with the previous evidence, the results indicate that fucoidan exerts prebiotic effects, such as lipid metabolism suppression and metabolic endotoxemia suppression, by modulating the abundance of gut microbiota, such as Lactobacillus animalis, Lactobacillus gasseri, and Lactobacillus reuteri, as well as microbiota-dependent metabolites, such as tryptophan-related metabolites. |
| WOS关键词 | GUT MICROBIOTA ; INFLAMMATORY RESPONSE ; VISCERAL FAT ; PROTECTS ; SUPPRESSES |
| WOS研究方向 | Engineering ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:000662447900001 |
| 资助机构 | Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Science and Technology Program of Yantai |
| 源URL | [http://ir.yic.ac.cn/handle/133337/34776]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 通讯作者 | Li, Lili |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Jingyi,Qin, Song,Li, Wenjun,et al. Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice[J]. JOURNAL OF MARINE SCIENCE AND ENGINEERING,2021,9(5):13. |
| APA | Yuan, Jingyi.,Qin, Song.,Li, Wenjun.,Zhang, Yubing.,Wang, Yuting.,...&Li, Lili.(2021).Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice.JOURNAL OF MARINE SCIENCE AND ENGINEERING,9(5),13. |
| MLA | Yuan, Jingyi,et al."Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice".JOURNAL OF MARINE SCIENCE AND ENGINEERING 9.5(2021):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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