Sea Cucumber Viscera Contains Novel Non-Holostane-Type Glycoside Toxins that Possess a Putative Chemical Defense Function
文献类型：期刊论文
| 作者 | Liu, Yanfang1,3; Lu, Zhen1; Yan, Zhi1,2; Lin, Ainuo1,3; Han, Shaoshuai1,4; Li, Yaxi1,3; Yang, Xiao1,3; Li, Xiaodong1; Yin, Xiuli1 ; Zhang, Ranran1,3
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| 刊名 | JOURNAL OF CHEMICAL ECOLOGY
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| 出版日期 | 2024-03-05 |
| 页码 | 12 |
| 关键词 | Saponin Viscera Non-holostane Acute toxicity Natural products Chemical defense |
| ISSN号 | 0098-0331 |
| DOI | 10.1007/s10886-024-01483-0 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Sea cucumbers frequently expel their guts in response to predators and an aversive environment, a behavior perceived as releasing repellents involved in chemical defense mechanisms. To investigate the chemical nature of the repellent, the viscera of stressed sea cucumbers (Apostichopus japonicus) in the Yellow Sea of China were collected and chemically analyzed. Two novel non-holostane triterpene glycosides were isolated, and the chemical structures were elucidated as 3 beta-O-[beta-D-glucopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-(20S)-hydroxylanosta-7,25-diene-18(16)-lactone (1) and 3 beta-O-[beta-D-quinovopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-(20S)-hydroxylanosta-7,25-diene-18(16)-lactone (2) by spectroscopic and mass-spectrometric analyses, exemplifying a triterpene glycoside constituent of an oligosaccharide containing two sugar-units and a non-holostane aglycone. Zebrafish embryos were exposed to various doses of 1 and 2 from 4 to 96 hpf. Compound 1 exposure showed 96 h-LC50 41.5 mu M and an increased zebrafish mortality rates in roughly in a dose- and time-dependent manner. Compound 2, with different sugar substitution, exhibited no mortality and moderate teratogenic toxicity with a 96 h-EC50 of 173.5 mu M. Zebrafish embryos exhibited teratogenic effects, such as reduced hatchability and total body length. The study found that triterpene saponin from A. japonicus viscera had acute toxicity in zebrafish embryos, indicating a potential chemical defense role in the marine ecosystem. |
| WOS关键词 | TRITERPENE GLYCOSIDES ; CUVIERIAN TUBULES ; SAPONINS ; ZEBRAFISH ; HOLOTHURIANS ; EFFICIENCY ; MODEL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001176417100001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/34915]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Harbin Inst Technol, Sch Marine Sci & Technol, Weihai 264209, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yanfang,Lu, Zhen,Yan, Zhi,et al. Sea Cucumber Viscera Contains Novel Non-Holostane-Type Glycoside Toxins that Possess a Putative Chemical Defense Function[J]. JOURNAL OF CHEMICAL ECOLOGY,2024:12. |
| APA | Liu, Yanfang.,Lu, Zhen.,Yan, Zhi.,Lin, Ainuo.,Han, Shaoshuai.,...&Li, Ke.(2024).Sea Cucumber Viscera Contains Novel Non-Holostane-Type Glycoside Toxins that Possess a Putative Chemical Defense Function.JOURNAL OF CHEMICAL ECOLOGY,12. |
| MLA | Liu, Yanfang,et al."Sea Cucumber Viscera Contains Novel Non-Holostane-Type Glycoside Toxins that Possess a Putative Chemical Defense Function".JOURNAL OF CHEMICAL ECOLOGY (2024):12. |
入库方式： OAI收割
来源：烟台海岸带研究所
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