Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity
文献类型：期刊论文
| 作者 | Liu, Yanfang1,3; Lu, Zhen1; Yan, Zhi2; Li, Xiaodong1; Yin, Xiuli1 ; Zhang, Ranran1,3; Li, Yaxi1; Wang, Song4; Xie, Ruliang4; Li, Ke1
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2024-03-29 |
| 页码 | 7 |
| 关键词 | Saponin viscera holostane acute toxicity chemical defense |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202400335 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Sea cucumbers release chemical repellents from their guts when they are in danger from predators or a hostile environment. To investigate the chemical structure of the repellent, we collected and chemically analyzed the viscera of stressed sea cucumbers (Apostichopus japonicus) in the Yellow Sea of China. Two undescribed triterpene glycosides (1 and 2), together with a known cladoloside A (3), were identified and elucidated as 3 beta-O-{2-O-[beta-d-quinovopyranosyl]-4-O-[3-O-methyl-beta-d-glucopyranosyl-(1 -> 3)-beta-d-glucopyranosyl]-beta-d-xylopyranosyl}-holosta-9(11),25(26)-dien-16-one (1), 3 beta-O-{2-O-[beta-d-glucopyranosyl]-4-O-[3-O-methyl-beta-d-glucopyranosyl-(1 -> 3)-beta-d-glucopyranosyl]-beta-d-xylopyranosyl}-holosta-9(11),25(26)-dien-16-one (2), 3 beta-O-{2-O-[3-O-methyl-beta-d-glucopyranosyl-(1 -> 3)-beta-d-xylopyranosyl-(1 -> 4)-beta-d-quinovopyranosyl]-beta-d-xylopyranosyl}-holosta-9(11),25(26)-dien-16-one (3) by spectroscopic analysis, including HR-ESI-MS and NMR spectra. Compounds 1, 2, and 3 display embryonic toxicity, as indicated by their 96-hour post-fertilization lethal concentration (96 hpf-LC50) values of 0.289, 0.536, and 0.091 mu M, respectively. Our study discovered a class of triterpene glycoside compounds consisting of an oligosaccharide with four sugar units and a holostane aglycone. These compounds possess embryotoxicity and may serve as chemical defense molecules in marine benthic ecosystems. |
| WOS关键词 | OLIGOGLYCOSIDES ; EFFICIENCY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001193765700001 |
| 资助机构 | National Natural Science Foundation of China ; STS Program of CAS ; Yantai Science and Technology Innovation Development Program ; Priority Academic Program Development of Jiangsu Higher Education Institutions ; Taishan Scholar Program from Shandong Province of China ; Yantai Municipal City's Shuangbai Plan |
| 源URL | [http://ir.yic.ac.cn/handle/133337/34945]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, 59 Cangwu Rd, Lianyungang 222005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yanfang,Lu, Zhen,Yan, Zhi,et al. Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity[J]. CHEMISTRY & BIODIVERSITY,2024:7. |
| APA | Liu, Yanfang.,Lu, Zhen.,Yan, Zhi.,Li, Xiaodong.,Yin, Xiuli.,...&Li, Ke.(2024).Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity.CHEMISTRY & BIODIVERSITY,7. |
| MLA | Liu, Yanfang,et al."Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity".CHEMISTRY & BIODIVERSITY (2024):7. |
入库方式： OAI收割
来源：烟台海岸带研究所
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