Phycocyanin attenuates X-ray-induced pulmonary infl ammation via the TLR2-MyD88-NF-κB signaling pathway
文献类型：期刊论文
| 作者 | LIU Qi1; LI Wenjun1 ; LU Lina3; LIU Bin3; DU Zhenning2; QIN Song1
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| 刊名 | 海洋湖沼学报(英文)
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| 出版日期 | 2019 |
| 卷号 | 37.0期号:005页码:1678-1685 |
| 关键词 | phycocyanin infl ammatory TLR2-MyD88-NF-κB signaling pathway |
| ISSN号 | 2096-5508 |
| 其他题名 | Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway |
| 英文摘要 | Phycocyanin (PC), a natural algal protein, is reported for having anti-oxidant and antiinfl ammatory properties. We investigated its ability to attenuate lung infl ammation in mice subjected to X-ray radiation. Male C57BL/6 mice were assigned to the control, total body irradiation, PC pretreatment, and PC treatment groups. Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation, and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation. Lungs were collected on Day 7 after irradiation exposure. Hematoxylin and eosin staining of mouse lung sections showed considerable infl ammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group. Pretreatment or treatment with PC signifi cantly decreased levels of interleukin-6 and tumor necrosis factor-α in the lung, and also increased the relative mRNA expression of superoxide dismutase and glutathione. In vivo, PC signifi cantly reduced the expression of Toll-like receptor TLR2, myeloid diff erentiation primary response Myd88, and nuclear factor NF-κB, at both the transcriptional and translation level. Taken together, these data indicated that PC attenuated lung infl ammatory damage induced by radiation by blocking the TLR2- MyD88-NF-κB signaling pathway. Therefore, PC could be a protective agent against radiation-induced infl ammatory damage in normal tissues. |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6556057 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/35043]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 作者单位 | 1.中国科学院烟台海岸带研究所 2.School of Pharmacy,Yantai University 3.School of Nuclear Science and Technology,Lanzhou University |
| 推荐引用方式 GB/T 7714 | LIU Qi,LI Wenjun,LU Lina,et al. Phycocyanin attenuates X-ray-induced pulmonary infl ammation via the TLR2-MyD88-NF-κB signaling pathway[J]. 海洋湖沼学报(英文),2019,37.0(005):1678-1685. |
| APA | LIU Qi,LI Wenjun,LU Lina,LIU Bin,DU Zhenning,&QIN Song.(2019).Phycocyanin attenuates X-ray-induced pulmonary infl ammation via the TLR2-MyD88-NF-κB signaling pathway.海洋湖沼学报(英文),37.0(005),1678-1685. |
| MLA | LIU Qi,et al."Phycocyanin attenuates X-ray-induced pulmonary infl ammation via the TLR2-MyD88-NF-κB signaling pathway".海洋湖沼学报(英文) 37.0.005(2019):1678-1685. |
入库方式： OAI收割
来源：烟台海岸带研究所
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