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Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems

文献类型：期刊论文

作者Ji, Yunxia1,2; Wang, Yunqing1; Wang, Xiaoyan5; Lv, Changjun2; Zhou, Qunfang4; Jiang, Guibin4; Yan, Bing3; Chen, Lingxin1
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2024-04-15
卷号468页码:21
关键词Complex interaction Toxic effect Nanoparticle Physiological system Biological system
ISSN号0304-3894
DOI10.1016/j.jhazmat.2024.133800
通讯作者Yan, Bing(drbingyan@yahoo.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要The exploration of nanoparticle applications is filled with promise, but their impact on the environment and human health raises growing concerns. These tiny environmental particles can enter the human body through various routes, such as the respiratory system, digestive tract, skin absorption, intravenous injection, and implantation. Once inside, they can travel to distant organs via the bloodstream and lymphatic system. This journey often results in nanoparticles adhering to cell surfaces and being internalized. Upon entering cells, nanoparticles can provoke significant structural and functional changes. They can potentially disrupt critical cellular processes, including damaging cell membranes and cytoskeletons, impairing mitochondrial function, altering nuclear structures, and inhibiting ion channels. These disruptions can lead to widespread alterations by interfering with complex cellular signaling pathways, potentially causing cellular, organ, and systemic impairments. This article delves into the factors influencing how nanoparticles behave in biological systems. These factors include the nanoparticles' size, shape, charge, and chemical composition, as well as the characteristics of the cells and their surrounding environment. It also provides an overview of the impact of nanoparticles on cells, organs, and physiological systems and discusses possible mechanisms behind these adverse effects. Understanding the toxic effects of nanoparticles on physiological systems is crucial for developing safer, more effective nanoparticlebased technologies.
WOS关键词TITANIUM-DIOXIDE NANOPARTICLES ; SILICA NANOPARTICLES ; GOLD NANOPARTICLES ; OXIDATIVE STRESS ; CELLULAR UPTAKE ; SILVER NANOPARTICLES ; PROTEIN CORONA ; GRAPHENE OXIDE ; CRUCIAL ROLE ; IN-VITRO
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001200134500001
资助机构Natural Science Foundation of Shandong Province of China ; Taishan Scholars Program ; Instru-ment Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Pearl River Talent Recruitment Program of Guangdong Province
源URL[http://ir.yic.ac.cn/handle/133337/35328]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Yan, Bing; Chen, Lingxin
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China
3.Guangzhou Univ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China
4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Ji, Yunxia,Wang, Yunqing,Wang, Xiaoyan,et al. Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,468:21.
APA Ji, Yunxia.,Wang, Yunqing.,Wang, Xiaoyan.,Lv, Changjun.,Zhou, Qunfang.,...&Chen, Lingxin.(2024).Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems.JOURNAL OF HAZARDOUS MATERIALS,468,21.
MLA Ji, Yunxia,et al."Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems".JOURNAL OF HAZARDOUS MATERIALS 468(2024):21.

入库方式： OAI收割

来源：烟台海岸带研究所

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