Objective： To investigate the deactivation of the depressive patients in the emotional cognitive tasks. Methods： Nine diagnosed depressive patients and nine age-matched healthy subjects completed the tasks requiring emotional picture processing. The deactivation of the two groups in the tasks was analyzed by SPM5 package. Results： Compared with healthy suhjects group, deactivation of depressive patients group was more apparent in the whole brain, especially in the cingulate gyrus, but not in the posterior cingulate gyrus. Conclusion： The reallocation of brain resources in the depressive patients group during emotional cognitive tasks is affected by the cognitive disfunction, resulting in abnormal deactivation.

目的:探讨抑郁症患者在情绪认知任务状态下的负激活变化规律。方法:选取9例确诊抑郁症患者和9例年龄相匹配的健康被试,以情绪图片判别作为刺激任务,比较两组被试在任务状态下负激活的差别。统计分析采用SPM5软件包完成。结果:相对于健康被试组,抑郁症患者组表现出更为显著的全脑负激活模式,但后扣带回负激活出现特征缺失。结论:抑郁症患者在执行情绪认知任务时,脑内出现更大的资源重分配过程,并具有特异性。

国家自然科学基金(30670699) 教育部新世纪优秀人才支持计划(NCET-06-0277)资助项目 大连理工大学人文社会科学研究基金资助(DUTHS2007333)