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Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-na?ve major depressive disorder and comorbid autoimmune thyroiditis

文献类型：期刊论文

作者Luo, Yinli5; Zhou, Yanan5; Peng, Pu3,4; Yuan, Ning5; Zhang, Xiangyang1,2
刊名BJPSYCH OPEN
出版日期2024-04-30
卷号10期号:3页码:7
关键词Anxiety autoimmune thyroiditis major depressive disorder suicide attempts first-episode drug-na & iuml ve
ISSN号2056-4724
DOI10.1192/bjo.2024.48
通讯作者Yuan, Ning(2147223726@qq.com)
英文摘要Background Autoimmune thyroiditis is closely associated with major depressive disorder (MDD) and suicide attempts. However, few studies have examined this relationship.Aims The study aimed to assess the prevalence and correlates of suicide attempts in patients with first-episode drug-na & iuml;ve (FEDN) MDD and autoimmune thyroiditis.Method We recruited 1718 out-patients with FEDN MDD and assessed depressive, anxiety and psychotic symptoms with the Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety (HRSA) and Positive and Negative Syndrome Subscale positive subscale, respectively. The serum levels of free triiodothyronine, free thyroxine, thyroid stimulating hormone (TSH), antithyroglobulin, thyroid peroxidase antibody (TPOAb) and several other metabolic parameters were assessed. Patients were divided into non-autoimmune thyroiditis, autoimmune thyroiditis only and autoimmune thyroiditis with abnormal TSH groups, based on autoimmune thyroiditis severity. Multiple logistic regression model was applied to identify the correlates of suicide attempts in patients with MDD and autoimmune thyroiditis with abnormal TSH.Results Compared with the non-autoimmune thyroiditis group, the autoimmune thyroiditis with abnormal TSH group had a nearly fourfold higher likelihood of reporting a suicide attempt, whereas no difference was found between the non-autoimmune thyroiditis and autoimmune thyroiditis only groups. HRSA score, lnTPOAb and lnTSH were independently associated with suicide attempts in patients with autoimmune thyroiditis with abnormal TSH.Conclusions Patients with MDD and autoimmune thyroiditis with abnormal TSH are at higher risk for suicide attempt. TPOAb, TSH and anxiety are all independently associated with suicide attempts in this population, and regular thyroid checks are warranted.
收录类别SCI
WOS关键词SUBCLINICAL HYPOTHYROIDISM ; ANXIETY
资助项目Key R&D Project of Hunan Provincial Department of Science and Technology[2022SK2044]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001211238800001
出版者CAMBRIDGE UNIV PRESS
资助机构Key R&D Project of Hunan Provincial Department of Science and Technology
源URL[http://ir.psych.ac.cn/handle/311026/47666]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Yuan, Ning
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China
4.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China
5.Hunan Brain Hosp, Hunan Peoples Hosp 2, Dept Psychiat, Changsha, Peoples R China
推荐引用方式
GB/T 7714		 Luo, Yinli,Zhou, Yanan,Peng, Pu,et al. Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-na?ve major depressive disorder and comorbid autoimmune thyroiditis[J]. BJPSYCH OPEN,2024,10(3):7.
APA Luo, Yinli,Zhou, Yanan,Peng, Pu,Yuan, Ning,&Zhang, Xiangyang.(2024).Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-na?ve major depressive disorder and comorbid autoimmune thyroiditis.BJPSYCH OPEN,10(3),7.
MLA Luo, Yinli,et al."Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-na?ve major depressive disorder and comorbid autoimmune thyroiditis".BJPSYCH OPEN 10.3(2024):7.

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来源：心理研究所

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