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Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review

文献类型：期刊论文

作者Wang, Jiaqi5,6; Gu, Ruolei4,5; Kong, Xiangzhen2,3; Luan, Shenghua4,5; Luo, Yu L. L.1,5,6
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
出版日期2024-06-08
卷号132页码:16
关键词Impulsivity Systematic review Genome-wide association studies (GWAS) Heritability Genetic correlation
ISSN号0278-5846
DOI10.1016/j.pnpbp.2024.110986
通讯作者Luo, Yu L. L.(luoy@psych.ac.cn)
英文摘要Impulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue. We conducted a systematic review of all GWAS and post-GWAS analyses of impulsivity published up to December 2023. Available data suggest that single nucleotide polymorphisms (SNPs) in more than a dozen of genes (e.g., CADM2, CTNNA2, GPM6B) are associated with different measures of impulsivity at genome-wide significant levels. Post-GWAS analyses further show that different measures of impulsivity are subject to different degrees of genetic influence, share few genetic variants, and have divergent genetic overlap with basic personality traits such as extroversion and neuroticism, cognitive ability, psychiatric disorders, substance use, and obesity. These findings shed light on controversies in the conceptualization and measurement of impulsivity, while providing new insights on the underlying mechanisms that yoke impulsivity to psychopathology.
收录类别SCI
WOS关键词ALPHA-N-CATENIN ; CELL-ADHESION ; MISSING HERITABILITY ; RESPONSE-INHIBITION ; MOLECULAR-GENETICS ; BIPOLAR DISORDER ; RECEPTOR BAI3 ; HUMAN BRAIN ; SELF-REPORT ; METAANALYSIS
资助项目Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3815CX] ; CAS Key Laboratory of Behavioral Science, Institute of Psychology[Y5CX052003] ; National Natural Science Foundation of China[32071083] ; National Natural Science Foundation of China[32171074] ; National Natural Science Foundation of China[32171031] ; Beijing Nova Program[20230484444]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:001208194200001
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; CAS Key Laboratory of Behavioral Science, Institute of Psychology ; National Natural Science Foundation of China ; Beijing Nova Program
源URL[http://ir.psych.ac.cn/handle/311026/47675]  
专题心理研究所_中国科学院心理健康重点实验室
心理研究所_中国科学院行为科学重点实验室
通讯作者Luo, Yu L. L.
作者单位1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, 3 Qingchundong Rd, Hangzhou 310016, Peoples R China
3.Zhejiang Univ, Dept Psychol & Behav Sci, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
6.Inst Psychol, Chinese Acad Sci, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jiaqi,Gu, Ruolei,Kong, Xiangzhen,et al. Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2024,132:16.
APA Wang, Jiaqi,Gu, Ruolei,Kong, Xiangzhen,Luan, Shenghua,&Luo, Yu L. L..(2024).Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,132,16.
MLA Wang, Jiaqi,et al."Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 132(2024):16.

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来源：心理研究所

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