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The regulation of social factors on anxiety and microglial activity in nucleus accumbens of adolescent male mice: Influence of social interaction strategy

文献类型：期刊论文

作者Zhao, Mingyue4,5; Xu, Xueping3; Xu, Hang5; Yang, Shuming1; Li, Man2,5; Wang, Weiwen4,5
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2024-05-01
卷号352页码:525-535
关键词Adolescence Physical and emotional stress Social support Social interaction strategies Microglia Nucleus Accumbens
ISSN号0165-0327
DOI10.1016/j.jad.2024.02.077
通讯作者Li, Man(jykxliman@tjnu.edu.cn) ; Wang, Weiwen(wangww@psych.ac.cn)
英文摘要Background: Adolescence is a period characterized by a high vulnerability to emotional disorders, which are modulated by biological, psychological, and social factors. However, the underlying mechanisms remain poorly understood. Methods: Combining physical or emotional social defeat stress (PS and ES) and pair or isolation rearing conditions, we investigated the effects of stress type and social support on emotional behavior and central immune molecules in adolescent mice, including anxiety, social fear, and social interaction strategies, as well as changes in microglia-specific molecules (ionized calcium-binding adaptor molecule 1 (Iba1) and a cluster of differentiation molecule 11b (CD11b)) in the medial prefrontal cortex (mPFC), hippocampus (HIP), amygdala (AMY), and nucleus accumbens (NAc). Results: Mice exposed to both physical stress and isolated rearing condition exhibited the highest levels of anxiety, social fear, and microglial CD11b expression in the NAc. In terms of social support, pair-housing with siblings ameliorated social fear and NAc molecular changes in ES mice, but not in PS mice. The reason for the differential benefit from social support was attributed to the fact that ES mice exhibited more active and less passive social strategies in social environment compared to PS mice. Further, the levels of stress-induced social fear were positively associated with the expression of microglial CD11b in the NAc. Conclusion: These findings offer extensive evidence regarding the intricate effects of multiple social factors on social anxiety and immune alteration in the NAc of adolescent mice. Additionally, they suggest potential behavioral and immune intervention strategies for anxiety-related disorders in adolescents.
收录类别SCI
WOS关键词NEGATIVE LIFE EVENTS ; STRESS ; DEPRESSION ; BRAIN ; BEHAVIOR ; ACTIVATION ; SUPPORT
资助项目National Natural Science Foundation of China[82071517] ; National Natural Science Foundation of China[U21A20364] ; National Natural Science Foundation of China[31771217] ; National Key Research and Development Program of China[2017YFE0126500] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001208469300001
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; National Key Research and Development Program of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/47678]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Man; Wang, Weiwen
作者单位1.Sun Yat Sen Univ, Zhongshan Sch Med, Div Clin Med, Guangzhou 510062, Guangdong, Peoples R China
2.Tianjin Normal Univ, Fac Psychol, Tianjin, Peoples R China
3.Capital Normal Univ, Coll Psychol, Beijing Key Lab Learning & Cognit, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Mingyue,Xu, Xueping,Xu, Hang,et al. The regulation of social factors on anxiety and microglial activity in nucleus accumbens of adolescent male mice: Influence of social interaction strategy[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,352:525-535.
APA Zhao, Mingyue,Xu, Xueping,Xu, Hang,Yang, Shuming,Li, Man,&Wang, Weiwen.(2024).The regulation of social factors on anxiety and microglial activity in nucleus accumbens of adolescent male mice: Influence of social interaction strategy.JOURNAL OF AFFECTIVE DISORDERS,352,525-535.
MLA Zhao, Mingyue,et al."The regulation of social factors on anxiety and microglial activity in nucleus accumbens of adolescent male mice: Influence of social interaction strategy".JOURNAL OF AFFECTIVE DISORDERS 352(2024):525-535.

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来源：心理研究所

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