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Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder

文献类型：期刊论文

作者Zhang, Jian-Jun4,5; Wang, Jingxia3; Wang, Xiao-Qian5; Zhang, Xiang-Yang1,2,4
刊名PSYCHOSOMATIC MEDICINE
出版日期2024-04-01
卷号86期号:3页码:202-209
关键词gender differences major depressive disorder metabolic syndrome first-episode and drug-naive patients
ISSN号0033-3174
DOI10.1097/PSY.0000000000001293
通讯作者Zhang, Xiang-Yang(zhangxy@psych.ac.cn)
英文摘要Objective Major depressive disorder (MDD) is a severe psychiatric symptom worldwide, and the coexistence of MDD with metabolic syndrome (MetS) is common in clinical practice. However, gender differences in comorbid MetS in first-episode and drug-naive (FEDN) MDD patients have not been reported. Here, we explored potential gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Methods A cross-sectional study of 1718 FEDN MDD patients was conducted. Demographic and clinical data were collected. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale, and Positive and Negative Syndrome Scale positive subscale were used to evaluate depression, anxiety, and psychotic symptoms, respectively. Results The prevalence of MetS was 1.645-fold higher in female MDD patients (38.50%) than in male patients (26.53%). Patients with MetS had higher HAMD score, Hamilton Anxiety Scale score, and Positive and Negative Syndrome Scale positive subscale score than patients without MetS (p values < .001). Furthermore, suicide attempts (male: odds ratio [OR] = 1.706, p = .034; female: OR = 1.639, p = .004) and HAMD score (male: OR = 1.251, p < .001; female: OR = 1.148, p < .001) were independently associated with MetS in male and female patients, whereas age of onset was independently associated with MetS only in female patients (OR = 1.744, p = .047). Conclusions Our findings suggest significant gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Clinical variables (suicide attempts and HAMD scores) may be independently associated with MetS in MDD patients.
收录类别SCI
WOS关键词HORMONE-BINDING GLOBULIN ; MENTAL-HEALTH SURVEY ; SEX-DIFFERENCES ; GENERAL-POPULATION ; SERUM TESTOSTERONE ; SOMATIC SYMPTOMS ; RISK-FACTORS ; OBESITY ; WOMEN ; AGE
资助项目Chinese National Programs for Brain Science and Brain-like Intelligence Technology[2021ZD0202102] ; National Natural Science Foundation of China[31871111] ; Shanxi Provincial Key Team for Science and Technology Innovation in Traditional Chinese Medicine Prevention and Treatment of Encephalopathy and New Drug Development[2013131022]
WOS研究方向Psychiatry ; Psychology
语种英语
WOS记录号WOS:001198478600004
出版者LIPPINCOTT WILLIAMS & WILKINS
资助机构Chinese National Programs for Brain Science and Brain-like Intelligence Technology ; National Natural Science Foundation of China ; Shanxi Provincial Key Team for Science and Technology Innovation in Traditional Chinese Medicine Prevention and Treatment of Encephalopathy and New Drug Development
源URL[http://ir.psych.ac.cn/handle/311026/47681]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiang-Yang
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Sch Nursing, Tianjin, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Shanxi Key Lab Chinese Med Encephalopathy, Jinzhong, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jian-Jun,Wang, Jingxia,Wang, Xiao-Qian,et al. Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder[J]. PSYCHOSOMATIC MEDICINE,2024,86(3):202-209.
APA Zhang, Jian-Jun,Wang, Jingxia,Wang, Xiao-Qian,&Zhang, Xiang-Yang.(2024).Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder.PSYCHOSOMATIC MEDICINE,86(3),202-209.
MLA Zhang, Jian-Jun,et al."Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder".PSYCHOSOMATIC MEDICINE 86.3(2024):202-209.

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来源：心理研究所

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