Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages
文献类型：期刊论文
| 作者 | Di, Yazheng6,7; Mefford, Joel5; Rahmani, Elior4; Wang, Jinhan3; Ravi, Vijay3; Gorla, Aditya2; Alwan, Abeer3; Zhu, Tingshao6,7 ; Flint, Jonathan1
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| 刊名 | COMMUNICATIONS BIOLOGY
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| 出版日期 | 2024-05-07 |
| 卷号 | 7期号:1页码:7 |
| DOI | 10.1038/s42003-024-06198-2 |
| 通讯作者 | Flint, Jonathan(JFlint@mednet.ucla.edu) |
| 英文摘要 | The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin). A GWAS finds genetic link in ABCC9 gene affecting vocal pitch in both Mandarin and Icelandic speakers, suggesting a shared genetic influence on human vocal systems across populations. |
| 收录类别 | SCI |
| WOS关键词 | INFERENCE |
| 资助项目 | U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)[MH-122596] ; NIH |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001215651900004 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) ; NIH |
| 源URL | [http://ir.psych.ac.cn/handle/311026/47653]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Flint, Jonathan |
| 作者单位 | 1.Univ Calif Los Angeles, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA 2.Univ Calif Los Angeles, Bioinformat Interdept Program, Los Angeles, CA USA 3.Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA USA 4.Univ Calif Los Angeles, Dept Computat Med, Los Angeles, CA USA 5.Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA USA 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 7.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Di, Yazheng,Mefford, Joel,Rahmani, Elior,et al. Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages[J]. COMMUNICATIONS BIOLOGY,2024,7(1):7. |
| APA | Di, Yazheng.,Mefford, Joel.,Rahmani, Elior.,Wang, Jinhan.,Ravi, Vijay.,...&Flint, Jonathan.(2024).Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages.COMMUNICATIONS BIOLOGY,7(1),7. |
| MLA | Di, Yazheng,et al."Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages".COMMUNICATIONS BIOLOGY 7.1(2024):7. |
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来源：心理研究所
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