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Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial

文献类型：期刊论文

作者Dang, Yi8; Lu, Bin5,6,7; Vanderwal, Tamara3,4; Castellanos, Francisco Xavier1,2; Yan, Chao-Gan5,6,7,8
刊名PSYCHOLOGICAL MEDICINE
出版日期2024-05-09
页码10
关键词antidepressant arterial spin labeling biomarker cerebral blood flow EMBARC
ISSN号0033-2917
DOI10.1017/S0033291724001156
通讯作者Yan, Chao-Gan(yancg@psych.ac.cn)
英文摘要Background Major depressive disorder (MDD) is one of the most prevalent and disabling illnesses worldwide. Treatment of MDD typically relies on trial-and-error to find an effective approach. Identifying early response-related biomarkers that predict response to antidepressants would help clinicians to decide, as early as possible, whether a particular treatment might be suitable for a given patient.Methods Data were from the two-stage Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) trial. A whole-brain, voxel-wise, mixed-effects model was applied to identify early-treatment cerebral blood flow (CBF) changes as biomarkers of treatment response. We examined changes in CBF measured with arterial spin labeling 1-week after initiating double-masked sertraline/placebo. We tested whether these early 1-week scans could be used to predict response observed after 8-weeks of treatment.Results Response to 8-week placebo treatment was associated with increased cerebral perfusion in temporal cortex and reduced cerebral perfusion in postcentral region captured at 1-week of treatment. Additionally, CBF response in these brain regions was significantly correlated with improvement in Hamilton Depression Rating Scale score in the placebo group. No significant associations were found for selective serotonin reuptake inhibitor treatment.Conclusions We conclude that early CBF responses to placebo administration in multiple brain regions represent candidate neural biomarkers of longer-term antidepressant effects.
收录类别SCI
WOS关键词MAJOR DEPRESSIVE DISORDER ; SPIN-LABELING MRI ; GRAY-MATTER ; BRAIN ; CONNECTIVITY ; PLACEBO ; CORTEX ; METAANALYSIS ; STATE
资助项目Technical Support Talents Project of Chinese Academy of Sciences[E2CX1154] ; Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology[2021ZD0200600] ; National Natural Science Foundation of China[82122035] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4425YZ] ; NIMH[U01MH092221] ; NIMH[U01MH092250]
WOS研究方向Psychology ; Psychiatry
语种英语
WOS记录号WOS:001215859000001
出版者CAMBRIDGE UNIV PRESS
资助机构Technical Support Talents Project of Chinese Academy of Sciences ; Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology ; National Natural Science Foundation of China ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; NIMH
源URL[http://ir.psych.ac.cn/handle/311026/47660]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Yan, Chao-Gan
作者单位1.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
2.NYU Robert I Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA
3.BC Childrens Hosp Res Inst, Vancouver, BC, Canada
4.Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada
5.Chinese Acad Sci, Inst Psychol, Int Big Data Ctr Depress Res, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Dang, Yi,Lu, Bin,Vanderwal, Tamara,et al. Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial[J]. PSYCHOLOGICAL MEDICINE,2024:10.
APA Dang, Yi,Lu, Bin,Vanderwal, Tamara,Castellanos, Francisco Xavier,&Yan, Chao-Gan.(2024).Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial.PSYCHOLOGICAL MEDICINE,10.
MLA Dang, Yi,et al."Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial".PSYCHOLOGICAL MEDICINE (2024):10.

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