Visible Light-Mediated Defluorination to Access 1,1-Difluoro-1,3-Enynes
文献类型：期刊论文
| 作者 | Wang, Xu1,2; Huang, Wei1,2; Zhang, Feng-Hua2 |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
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| 出版日期 | 2024-04-17 |
| 页码 | 7 |
| 关键词 | photoredox catalysis 1,1-difluoro-1,3-enynes acid metal free redox-neutral |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.202400183 |
| 通讯作者 | Zhang, Feng-Hua(zhangfenghua01@ucas.ac.cn) |
| 英文摘要 | Herein, a visible light-mediated defluorination reaction to access 1,1-difluoro-1,3-enynes is described. Compared with previous studies, this protocol employs more readily accessible acids as a radical precursor under redox-neutral conditions. Moreover, the reaction exhibits high compatibility with diverse primary, secondary and tertiary acids, especially natural amino acids and drug-derived acids. Preliminary mechanistic investigations reveal that a radical pathway is involved in the catalytic cycle. image |
| WOS关键词 | FLUORINE |
| 资助项目 | Zhejiang Provincial Natural Science Foundation of China ; Hangzhou innovation and entrepreneurship leading team project[TD2020005] ; [LQ24B020006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001204129300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310623]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Feng-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xu,Huang, Wei,Zhang, Feng-Hua. Visible Light-Mediated Defluorination to Access 1,1-Difluoro-1,3-Enynes[J]. ADVANCED SYNTHESIS & CATALYSIS,2024:7. |
| APA | Wang, Xu,Huang, Wei,&Zhang, Feng-Hua.(2024).Visible Light-Mediated Defluorination to Access 1,1-Difluoro-1,3-Enynes.ADVANCED SYNTHESIS & CATALYSIS,7. |
| MLA | Wang, Xu,et al."Visible Light-Mediated Defluorination to Access 1,1-Difluoro-1,3-Enynes".ADVANCED SYNTHESIS & CATALYSIS (2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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